Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 4/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.43 |
| ▸ | RXRA | P19793 | 4/20 | 0.43 |
| ▸ | RXRB | P28702 | 4/20 | 0.43 |
| ▸ | RXRG | P48443 | 4/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10429369 | 0.83 | GPR52 (0.45) | S1PR1S1PR5 | |
| SCHEMBL10429358 | 0.79 | PARP10 (0.55) | — | |
| SCHEMBL27612935 | 0.73 | CTSS (0.48) | S1PR1MRGPRX4CTSSS1PR4S1PR3 | |
| SCHEMBL10429353 | 0.72 | KDM4E (0.55) | SYK | |
| SCHEMBL1758364 | 0.72 | IKBKB (0.47) | — | |
| SCHEMBL16739630 | 0.71 | CDC7 (0.52) | — | |
| SCHEMBL10429348 | 0.71 | CTSS (0.44) | S1PR1MRGPRX4RXRARXRBRXRG | |
| SCHEMBL656838 | 0.71 | MRGPRX4 (0.50) | S1PR1MRGPRX4RXRARXRBRXRG | |
| SCHEMBL79709 | 0.70 | RXRA (0.72) | MRGPRX4RXRARXRBRXRGPTGER1 | |
| SCHEMBL10429335 | 0.70 | LMNA (0.46) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4920119-A | XANTHINE OXIDASE INHIBITORS; CONTROL OR PREVENTION OF GOUT OR ISCHEMIA | HOFFMANN-LA ROCHE INC. (US) | 1990-04-24 | — | — | US | disclosed |
| EP-0274654-A2 | 1,2,3-Triazin-4(3H)-one derivatives, process for their preparation and medicaments containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1988-07-20 | — | — | EP | disclosed |