Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10429315 | 0.81 | ALDH1A1 (0.50) | LMNAL3MBTL1SMN1; SMN2TP53KDM4E | |
| SCHEMBL10429308 | 0.81 | SMN1; SMN2 (0.50) | LMNAL3MBTL1SMN1; SMN2TP53KDM4E | |
| SCHEMBL10429355 | 0.73 | DAPK3 (0.52) | LMNASMN1; SMN2TP53KDM4ETSHR | |
| SCHEMBL10429338 | 0.69 | KMT2A (0.46) | LMNAL3MBTL1SMN1; SMN2TP53MAPT | |
| SCHEMBL17869828 | 0.65 | HTT (0.50) | LMNAESR1L3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL16285366 | 0.64 | MGLL (0.44) | SMN1; SMN2TP53KDM4EALDH1A1NPBWR1 | |
| SCHEMBL11955384 | 0.63 | SMN1; SMN2 (0.44) | LMNAL3MBTL1SMN1; SMN2TP53KDM4E | |
| SCHEMBL10360610 | 0.62 | NPC1 (0.73) | LMNAL3MBTL1SMN1; SMN2TP53KDM4E | |
| SCHEMBL28644729 | 0.62 | MGLL (0.46) | LMNASMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL17869860 | 0.62 | HTT (0.67) | LMNAESR1L3MBTL1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0274654-A2 | 1,2,3-Triazin-4(3H)-one derivatives, process for their preparation and medicaments containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1988-07-20 | — | — | EP | claimed |
| US-4920119-A | XANTHINE OXIDASE INHIBITORS; CONTROL OR PREVENTION OF GOUT OR ISCHEMIA | HOFFMANN-LA ROCHE INC. (US) | 1990-04-24 | — | — | US | disclosed |
| EP-0274654-A2 | 1,2,3-Triazin-4(3H)-one derivatives, process for their preparation and medicaments containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1988-07-20 | — | — | EP | disclosed |