Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | XDH | P47989 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10429315 | 0.81 | ALDH1A1 (0.50) | SMN1; SMN2KMT2AMEN1HTTLMNA | |
| SCHEMBL10429351 | 0.81 | LMNA (0.44) | SMN1; SMN2HTTLMNATSHRALDH1A1 | |
| SCHEMBL10429319 | 0.80 | POLB (0.50) | SMN1; SMN2LMNAPOLBRAB9AALDH1A1 | |
| SCHEMBL17869621 | 0.78 | XDH (0.60) | SMN1; SMN2KMT2AMEN1XDHHTT | |
| SCHEMBL10429355 | 0.73 | DAPK3 (0.52) | SMN1; SMN2KMT2ALMNATSHRHPGD | |
| SCHEMBL23047007 | 0.71 | SMN1; SMN2 (0.51) | SMN1; SMN2KMT2AMEN1XDHHTT | |
| SCHEMBL19342074 | 0.69 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AMEN1XDHHTT | |
| SCHEMBL10429338 | 0.69 | KMT2A (0.46) | SMN1; SMN2KMT2AMEN1XDHHTT | |
| SCHEMBL8306261 | 0.69 | PDE9A (0.64) | SMN1; SMN2KMT2AMEN1HTTLMNA | |
| SCHEMBL9918804 | 0.68 | CMA1 (0.43) | KMT2AMEN1LMNAPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0274654-A2 | 1,2,3-Triazin-4(3H)-one derivatives, process for their preparation and medicaments containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1988-07-20 | — | — | EP | claimed |
| US-4920119-A | XANTHINE OXIDASE INHIBITORS; CONTROL OR PREVENTION OF GOUT OR ISCHEMIA | HOFFMANN-LA ROCHE INC. (US) | 1990-04-24 | — | — | US | disclosed |
| EP-0274654-A2 | 1,2,3-Triazin-4(3H)-one derivatives, process for their preparation and medicaments containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1988-07-20 | — | — | EP | disclosed |