Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAPK3 | O43293 | 2/20 | 0.52 |
| ▸ | PIM1 | P11309 | 2/20 | 0.52 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.52 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.52 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.49 |
| ▸ | DAPK2 | Q9UIK4 | 1/20 | 0.49 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 7/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10429315 | 0.84 | ALDH1A1 (0.50) | DAPK3PIM1PIM3TP53MAPT | |
| SCHEMBL10429338 | 0.82 | KMT2A (0.46) | TP53MAPTHPGDKMT2ASMN1; SMN2 | |
| SCHEMBL19342122 | 0.76 | DAPK3 (0.61) | DAPK3PIM1PIM3PIM2DAPK1 | |
| SCHEMBL19342126 | 0.74 | DAPK3 (0.70) | DAPK3PIM1PIM3PIM2DAPK1 | |
| SCHEMBL10429308 | 0.73 | SMN1; SMN2 (0.50) | TP53MAPTALDH1A1HPGDKDM4E | |
| SCHEMBL10429351 | 0.73 | LMNA (0.44) | TP53MAPTALDH1A1KDM4ETSHR | |
| SCHEMBL2786336 | 0.70 | GRM1 (0.55) | DAPK3PIM1PIM3PIM2DAPK1 | |
| SCHEMBL6224500 | 0.70 | MAPT (0.65) | TP53MAPTALDH1A1HPGDKDM4E | |
| SCHEMBL19342056 | 0.69 | DAPK3 (0.73) | DAPK3PIM1PIM3PIM2DAPK1 | |
| SCHEMBL8306675 | 0.69 | PDE9A (0.73) | DAPK3PIM1PIM3PIM2DAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0274654-A2 | 1,2,3-Triazin-4(3H)-one derivatives, process for their preparation and medicaments containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1988-07-20 | — | — | EP | claimed |
| US-4920119-A | XANTHINE OXIDASE INHIBITORS; CONTROL OR PREVENTION OF GOUT OR ISCHEMIA | HOFFMANN-LA ROCHE INC. (US) | 1990-04-24 | — | — | US | disclosed |
| EP-0274654-A2 | 1,2,3-Triazin-4(3H)-one derivatives, process for their preparation and medicaments containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1988-07-20 | — | — | EP | disclosed |