Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 2/20 | 0.53 |
| ▸ | KMO | O15229 | 2/20 | 0.48 |
| ▸ | RORB | Q92753 | 5/20 | 0.46 |
| ▸ | TDO2 | P48775 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5178386 | 0.84 | PARP1 (0.58) | KDM4EPARP1KMORORBKIF11 | |
| SCHEMBL1758364 | 0.78 | IKBKB (0.47) | KDM4EPARP1JAK2KDR | |
| SCHEMBL8936345 | 0.76 | KMO (0.54) | KDM4EKMORORBTDO2ADORA2A | |
| SCHEMBL9002267 | 0.75 | RORB (0.56) | PARP1KMORORBTDO2RORC | |
| SCHEMBL34469502 | 0.75 | KDM4E (0.51) | KDM4EPARP1KMOKIF11AURKA | |
| SCHEMBL11401523 | 0.75 | PARP1 (0.51) | KDM4EPARP1RORBKIF11ADORA2A | |
| SCHEMBL34469496 | 0.75 | PARP1 (0.54) | KDM4EPARP1KMORORBKIF11 | |
| SCHEMBL10429369 | 0.74 | GPR52 (0.45) | KDM4ERORBGPR52 | |
| SCHEMBL4724483 | 0.74 | PARP1 (0.59) | KDM4EPARP1RORBKIF11ADORA1 | |
| SCHEMBL473595 | 0.74 | ALDH1A1 (0.59) | KDM4EPARP1KMORORBTDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4920119-A | XANTHINE OXIDASE INHIBITORS; CONTROL OR PREVENTION OF GOUT OR ISCHEMIA | HOFFMANN-LA ROCHE INC. (US) | 1990-04-24 | — | — | US | disclosed |