Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | ACP1 | P24666 | 1/20 | 0.40 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | PAK1 | Q13153 | 4/20 | 0.36 |
| ▸ | STK10 | O94804 | 1/20 | 0.36 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10439648 | 0.84 | RAPGEF4 (0.40) | LMNAMAPTRAPGEF4TOP2ATOP2B | |
| SCHEMBL10439644 | 0.83 | NPC1 (0.48) | NPC1LMNAMAPTHTTENPP2 | |
| SCHEMBL11232526 | 0.81 | MAPT (0.49) | NPC1LMNAMAPTHTTENPP2 | |
| SCHEMBL10439645 | 0.78 | RAPGEF4 (0.42) | LMNAMAPTRAPGEF4TOP2ATOP2B | |
| SCHEMBL10439857 | 0.78 | TOP2A (0.56) | ENPP2RAPGEF4TOP2ATOP2BABL1 | |
| SCHEMBL10439650 | 0.75 | RAPGEF4 (0.41) | LMNAMAPTRAPGEF4TDP1TOP2A | |
| SCHEMBL2062260 | 0.75 | BCL6 (0.42) | ACP1PAK1TNIK | |
| SCHEMBL24082862 | 0.74 | ENPP2 (0.49) | NPC1LMNAMAPTHTTENPP2 | |
| SCHEMBL1425327 | 0.73 | PTGS2 (0.54) | — | |
| SCHEMBL3203509 | 0.73 | ROCK1 (0.46) | NPC1ACP1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0377896-A2 | Cyclooxygenase and 5-lipoxygenase inhibiting hydroxamic acid derivatives | CIBA-GEIGY AG (CH) | 1990-07-18 | — | — | EP | disclosed |