Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.40 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.36 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.35 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.35 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10439609 | 0.84 | NPC1 (0.43) | RAPGEF4TOP2ATOP2BMEN1LMNA | |
| SCHEMBL10439650 | 0.79 | RAPGEF4 (0.41) | RAPGEF4TOP2ATOP2BCAMK2AMEN1 | |
| SCHEMBL10439645 | 0.78 | RAPGEF4 (0.42) | RAPGEF4TOP2ATOP2BCAMK2AMEN1 | |
| SCHEMBL10439857 | 0.78 | TOP2A (0.56) | RAPGEF4TOP2ATOP2BALDH1A1SIGMAR1 | |
| SCHEMBL1425327 | 0.76 | PTGS2 (0.54) | CAMK2APTGS2CXCL8PTGS1AKR1B10 | |
| SCHEMBL6895272 | 0.72 | MEN1 (0.41) | MEN1KMT2A | |
| SCHEMBL1759063 | 0.71 | TAAR1 (0.55) | SIGMAR1CYP3A4TSHR | |
| SCHEMBL4786132 | 0.69 | TTR (0.60) | CAMK2AALDH1A1LMNAKMT2APTGS2 | |
| SCHEMBL9781898 | 0.69 | NR3C1 (0.52) | ALDH1A1LMNAPTGS1ADRA1ACYP3A4 | |
| SCHEMBL11202832 | 0.69 | NPSR1 (0.55) | MEN1ALDH1A1MAPTKMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0377896-A2 | Cyclooxygenase and 5-lipoxygenase inhibiting hydroxamic acid derivatives | CIBA-GEIGY AG (CH) | 1990-07-18 | — | — | EP | disclosed |