Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.42 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10439857 | 0.82 | TOP2A (0.56) | RAPGEF4TOP2ATOP2BALDH1A1SIGMAR1 | |
| SCHEMBL10439650 | 0.79 | RAPGEF4 (0.41) | RAPGEF4TOP2ATOP2BALDH1A1TRPA1 | |
| SCHEMBL10879892 | 0.79 | MAPT (0.42) | ALDH1A1TSHRSIGMAR1APPNR4A2 | |
| SCHEMBL10439648 | 0.78 | RAPGEF4 (0.40) | RAPGEF4TOP2ATOP2BALDH1A1TRPA1 | |
| SCHEMBL10439609 | 0.78 | NPC1 (0.43) | RAPGEF4TOP2ATOP2BMEN1KMT2A | |
| SCHEMBL4151489 | 0.77 | ALDH1A1 (0.60) | RAPGEF4TOP2ATOP2BALDH1A1TRPA1 | |
| SCHEMBL1425327 | 0.77 | PTGS2 (0.54) | TRPA1ADRA1ACAMK2AAKR1B10UGT1A9 | |
| SCHEMBL10878908 | 0.73 | MEN1 (0.43) | RAPGEF4ALDH1A1TRPA1TSHRAPP | |
| SCHEMBL10875466 | 0.73 | NPSR1 (0.60) | RAPGEF4ALDH1A1MAPTPOLB | |
| SCHEMBL29015003 | 0.72 | ALDH1A1 (0.44) | RAPGEF4TOP2ATOP2BALDH1A1TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0377896-A2 | Cyclooxygenase and 5-lipoxygenase inhibiting hydroxamic acid derivatives | CIBA-GEIGY AG (CH) | 1990-07-18 | — | — | EP | disclosed |