Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.56 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 3/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.43 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.42 |
| ▸ | NHERF1 | O14745 | 2/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10439645 | 0.82 | RAPGEF4 (0.42) | TOP2ATOP2BABL1RAPGEF4ALDH1A1 | |
| SCHEMBL10439813 | 0.81 | HDAC6 (0.42) | TOP2ATOP2BMAP2K4 | |
| SCHEMBL1425327 | 0.80 | PTGS2 (0.54) | — | |
| SCHEMBL10439650 | 0.79 | RAPGEF4 (0.41) | TOP2ATOP2BABL1RAPGEF4ALDH1A1 | |
| SCHEMBL11232384 | 0.79 | TOP2A (0.49) | TOP2ATOP2BABL1SYKFLT1 | |
| SCHEMBL10439609 | 0.78 | NPC1 (0.43) | TOP2ATOP2BABL1RAPGEF4ENPP2 | |
| SCHEMBL10439648 | 0.78 | RAPGEF4 (0.40) | TOP2ATOP2BABL1RAPGEF4ALDH1A1 | |
| SCHEMBL1520754 | 0.77 | TOP2A (0.63) | TOP2ATOP2BSYKFLT1FLT4 | |
| SCHEMBL2121710 | 0.75 | NFKB1 (0.59) | TOP2ATOP2BABL1SYKFLT1 | |
| SCHEMBL4786132 | 0.73 | TTR (0.60) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0377896-A2 | Cyclooxygenase and 5-lipoxygenase inhibiting hydroxamic acid derivatives | CIBA-GEIGY AG (CH) | 1990-07-18 | — | — | EP | disclosed |