Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10439676 | 0.82 | RAB9A (0.53) | NPC1RAB9AMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL17710702 | 0.80 | LMNA (0.45) | NPC1RAB9AMAPTSMN1; SMN2LMNA | |
| SCHEMBL2203682 | 0.72 | CES2 (0.52) | NPC1RAB9AMAPTSMN1; SMN2LMNA | |
| SCHEMBL11530620 | 0.70 | MAPT (0.44) | NPC1RAB9AMAPTALOX15SMN1; SMN2 | |
| SCHEMBL29926214 | 0.69 | MAPT (0.60) | NPC1RAB9AMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL29441487 | 0.67 | AR (0.41) | MAPTALOX15SMN1; SMN2LMNAALOX5 | |
| SCHEMBL11930062 | 0.66 | ALOX15 (0.64) | NPC1RAB9AMAPTALOX15SMN1; SMN2 | |
| SCHEMBL11534252 | 0.66 | NPC1 (0.48) | NPC1RAB9AMAPTALOX15SMN1; SMN2 | |
| SCHEMBL10439698 | 0.66 | ALOX15 (0.48) | NPC1RAB9AMAPTALOX15SMN1; SMN2 | |
| SCHEMBL5989988 | 0.65 | LMNA (0.48) | NPC1RAB9AMAPTALOX15SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0399773-A1 | Novel 7-aroyl-4-hydroxy-3-methyl benzolfurans as dual inhibitors of cyclooxygenase and 5-lipoxygenase | MERCK & CO. INC. (US) | 1990-11-28 | — | — | EP | disclosed |