SCHEMBL10443717

SCHEMBL10443717

CC(C)CNC(=O)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1c[nH]cn1)N(C(=O)OCc1ccccc1)C(=O)[C@@H](N)Cc1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ REN P00797 20/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10443554 0.85 REN (0.55) REN
SCHEMBL10444046 0.85 REN (0.55) REN
SCHEMBL10443715 0.84 REN (0.55) REN
SCHEMBL10443798 0.84 REN (0.55) REN
SCHEMBL10754244 0.82 CTSL (0.38) REN
SCHEMBL9876548 0.81 REN (0.49) REN
SCHEMBL10444085 0.81 REN (0.56) REN
SCHEMBL9876341 0.81 REN (0.54) REN
SCHEMBL9876598 0.80 REN (0.52) REN
SCHEMBL7308409 0.80 ACE2 (0.43) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0350163-A2 Renin inhibitory peptides BEECHAM GROUP PLC (GB) 1990-01-10 — — EP disclosed
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