Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.43 |
| ▸ | ECE1 | P42892 | 7/20 | 0.42 |
| ▸ | MME | P08473 | 6/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
| ▸ | MMP14 | P50281 | 2/20 | 0.41 |
| ▸ | MMP7 | P09237 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.39 |
| ▸ | CPA1 | P15085 | 1/20 | 0.38 |
| ▸ | CPB1 | P15086 | 1/20 | 0.38 |
| ▸ | CPA2 | P48052 | 1/20 | 0.38 |
| ▸ | CPA4 | Q9UI42 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7283367 | 0.84 | ACE2 (0.51) | ACE2ECE1MMEMMP2MMP9 | |
| SCHEMBL7284698 | 0.84 | ACE2 (0.51) | ACE2ECE1MMEMMP2MMP9 | |
| SCHEMBL7308401 | 0.84 | ECE1 (0.53) | ACE2ECE1MMEMMP2MMP9 | |
| SCHEMBL10754244 | 0.80 | CTSL (0.38) | MMP2 | |
| SCHEMBL10443717 | 0.80 | REN (0.45) | — | |
| SCHEMBL9876548 | 0.77 | REN (0.49) | — | |
| SCHEMBL9876341 | 0.77 | REN (0.54) | — | |
| SCHEMBL9876598 | 0.76 | REN (0.52) | — | |
| SCHEMBL10716071 | 0.76 | ACE2 (0.67) | ACE2ECE1MME | |
| SCHEMBL7274793 | 0.76 | REN (0.46) | ACE2MMP2MMP9MMP8ANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0209897-A2 | Peptide enzyme inhibitors | MERCK & CO. INC. (US) | 1987-01-28 | — | — | EP | disclosed |