SCHEMBL104443

SCHEMBL104443

Brc1cnc2c(c1)OCCO2

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 2/20 0.42
MAPT P10636 2/20 0.42
LMNA P02545 1/20 0.42
BLM P54132 1/20 0.42
IDO1 P14902 1/20 0.35
MAOB P27338 2/20 0.35
KMT2A Q03164 1/20 0.34
DYRK1A Q13627 2/20 0.34
NPC1 O15118 2/20 0.34
RAB9A P51151 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
TP53 P04637 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
EGFR P00533 4/20 0.33
ADRA2A P08913 1/20 0.32
MAOA P21397 1/20 0.31
USP9X Q93008 1/20 0.31
ITGB2 P05107 1/20 0.31
ICAM1 P05362 1/20 0.31
ITGAL P20701 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21461907 0.92 HTT (0.36) HTTMAPTLMNABLMIDO1
SCHEMBL620776 0.83 MAPT (0.36) HTTMAPTIDO1MAOBKMT2A
SCHEMBL30203761 0.82 IDO1 (0.34) HTTMAPTIDO1KMT2ADYRK1A
SCHEMBL11999826 0.75 RAB9A (0.37) MAPTNPC1RAB9ASMN1; SMN2USP9X
SCHEMBL21603162 0.75 STIM1 (0.33) MAPTLMNAKMT2ANPC1RAB9A
SCHEMBL23109661 0.75 IDO1 (0.35) HTTLMNAIDO1TP53USP9X
SCHEMBL16754543 0.75 MAPT (0.41) MAPTKMT2ANPC1RAB9ASMN1; SMN2
SCHEMBL4140066 0.75 USP9X (0.32) USP9XITGB2ICAM1ITGALRHOA
SCHEMBL618866 0.73 IDO1 (0.34) HTTIDO1KMT2ADYRK1A
Hydrochloric Acid SCHEMBL31177637 0.73 MAPT (0.44) MAPTKMT2ANPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 234 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11071725-B2 Activating pyruvate kinase R FORMA THERAPEUTICS, INC. (US) 2021-07-27 US claimed
EP-4721737-A1 USE OF PHARMACEUTICAL COMPOSITION COMPRISING COMPOUND HAVING BIS(AZANYLYLIDENE) SULFONYL STRUCTURE FOR TREATING ANEMIA-RELATED DISEASES Scinnohub Pharmaceutical Co., Ltd. (CN) 2026-04-08 EP disclosed
US-20260085082-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE IMAGO BIOSCIENCES, INC. (US) 2026-03-26 US disclosed
US-12528822-B2 Cycloalkane-1,3-diamine derivative DAIICHI SANKYO COMPANY, LIMITED (JP) 2026-01-20 US disclosed
EP-4637760-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE Imago Biosciences Inc. (US) 2025-10-29 EP disclosed
EP-4622958-A1 SYNTHESIS OF PYRROLO[3,4-C]PYRROLES Novo Nordisk Health Care AG (CH) 2025-10-01 EP disclosed
EP-4617276-A2 PYRUVATE KINASE R (PKR) ACTIVATING COMPOSITIONS Novo Nordisk Health Care AG (CH) 2025-09-17 EP disclosed
EP-4031133-B1 PYRUVATE KINASE R (PKR) ACTIVATING COMPOSITIONS NOVO NORDISK HEALTHCARE AG (CH) 2025-08-13 EP disclosed
US-20250145635-A1 COMPOUND CONTAINING BIS(AZANYLYLIDENE) SULFONYL STRUCTURE AND USE THEREOF IN MEDICINE SCINNOHUB PHARMACEUTICAL CO., LTD. (CN) 2025-05-08 US disclosed
US-20250099481-A1 BCL-2 INHIBITORS NEWAVE PHARMACEUTICAL INC. 2025-03-27 US disclosed
US-6455554-B1 COMPOUNDS CAPABLE OF AFFECTING NICOTINIC CHOLINERGIC RECEPTORS; TREATOMG CENTRAL NERVOUS SYSTEM DISORDERS TARGACEPT, INC. 2002-09-24 US disclosed
US-6432954-B1 CENTRAL NERVOUS SYSTEM DISORDERS TARGACEPT, INC. 2002-08-13 US disclosed
EP-1225955-A1 ARYL OLEFINIC AZACYCLIC, AND ARYL ACETYLENIC AZACYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS Targacept, Inc. (US) 2002-07-31 EP disclosed
WO-2002056882-A1 QUINOLINES AND NITROGENATED DERIVAIVE THEREOF SUBSTITUTED IN 4-POSITION BY A PIPERIDINE-CONTAINING MOIETY AND THEIR USE AS ANTIBACTERIAL AGENTS SMITHKLINE BEECHAM P.L.C. (GB) 2002-07-25 WO disclosed
US-20020058652-A1 Pharmaceutical compositions and methods for use TARGACEPT, INC. 2002-05-16 US disclosed
EP-1185514-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE Targacept, Inc. (US) 2002-03-13 EP disclosed
WO-2002005801-A2 COMPOSITIONS CONTAINING DIACYLTARTARIC SALTS OF (E)-METANICOTINE TARGACEPT, INC. (US) 2002-01-24 WO disclosed
WO-2002005798-A2 PHARMACEUTICAL COMPOSITIONS FOR TREATING NEUROLOGICAL DISORDERS TARGACEPT, INC. (US) 2002-01-24 WO disclosed
WO-2001032264-A1 ARYL OLEFINIC AZACYCLIC, AND ARYL ACETYLENIC AZACYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS TARGACEPT, INC. (US) 2001-05-10 WO disclosed
WO-2000075110-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE TARGACEPT, INC. (US) 2000-12-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020058652-A1 Pharmaceutical compositions and methods for use CYP3A7, AADAC, CYP2B6 HTT 1097/4885MAPT 2733/4885LMNA 1971/4885
US-20250099481-A1 BCL-2 INHIBITORS BCL2, BCL2L1, BCL2L10 HTT 3033/4885MAPT 4367/4885LMNA 893/4885
US-20250145635-A1 COMPOUND CONTAINING BIS(AZANYLYLIDENE) SULFONYL STRUCTURE AND USE THEREOF IN MEDICINE BCL9, USP9X, BCL9L HTT 2375/4885MAPT 3783/4885LMNA 1053/4885
US-20260085082-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE KDM1B, KDM1A, KDM5C HTT 1761/4885MAPT 2266/4885LMNA 597/4885
US-11071725-B2 Activating pyruvate kinase R PCK1, PDK1, GCKR HTT 3131/4885MAPT 2180/4885LMNA 1465/4885
US-12528822-B2 Cycloalkane-1,3-diamine derivative MLLT1, MLLT3, PRMT6 HTT 4310/4885MAPT 3711/4885LMNA 1233/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.