SCHEMBL10444591

SCHEMBL10444591

C[Si](Cl)(CCl)c1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.38
ESR2 Q92731 1/20 0.38
MAPT P10636 1/20 0.34
ALDH1A1 P00352 2/20 0.32
LMNA P02545 1/20 0.32
NR1H2 P55055 2/20 0.31
NR1H3 Q13133 2/20 0.31
TP53 P04637 1/20 0.31
KMT2A Q03164 1/20 0.30
TRPA1 O75762 1/20 0.30
MAPK1 P28482 1/20 0.30
GSK3B P49841 1/20 0.30
HIF1A Q16665 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10533114 0.87 CYP1A2 (0.39) ESR1ESR2MAPTALDH1A1LMNA
SCHEMBL2273904 0.80 ESR1 (0.38) ESR1ESR2MAPTALDH1A1LMNA
SCHEMBL11523312 0.78 ACHE (0.38) MAPTALDH1A1LMNATP53
SCHEMBL11519758 0.78 LMNA (0.38) MAPTALDH1A1LMNAKMT2AGSK3B
SCHEMBL8908096 0.78 ESR1 (0.33) ESR1ESR2MAPT
SCHEMBL852172 0.77 MAPT (0.44) ESR1ESR2MAPTALDH1A1LMNA
SCHEMBL1270667 0.77 ESR1 (0.39) ESR1ESR2MAPTALDH1A1LMNA
SCHEMBL1313499 0.76 ESR1 (0.35) ESR1ESR2MAPTALDH1A1TP53
SCHEMBL4682428 0.76 NR1H2 (0.40) ESR1ESR2MAPTALDH1A1NR1H2
SCHEMBL15413402 0.75 ESR1 (0.38) ESR1ESR2MAPTALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113244761-B Mixed silicone oil for capturing acid gas through phase change and preparation method thereof 昆明理工大学 2023-07-07 CN claimed
CN-113244761-A Mixed silicone oil for capturing acid gas through phase change and preparation method thereof 昆明理工大学 2021-08-13 CN claimed
CN-113244761-B Mixed silicone oil for capturing acid gas through phase change and preparation method thereof 昆明理工大学 2023-07-07 CN disclosed
CN-113244761-A Mixed silicone oil for capturing acid gas through phase change and preparation method thereof 昆明理工大学 2021-08-13 CN disclosed
CN-113136092-A Antibacterial and antistatic APET composite material and preparation method thereof 河南银金达新材料股份有限公司 2021-07-20 CN disclosed
CN-106519454-A Polypropylene antibacterial material and preparation method thereof 南京悠谷知识产权服务有限公司 2017-03-22 CN disclosed
EP-0363584-A2 Silylation method GENERAL ELECTRIC COMPANY (US) 1990-04-18 EP disclosed
EP-0068813-B1 FUNGICIDAL 1,2,4-TRIAZOLE AND IMIDAZOLE DERIVATIVES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1985-09-25 EP disclosed
US-4510136-A A 1-SILYLMETHYL DERIVATIVE; AGRICULTURE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1985-04-09 US disclosed
US-4496551-A Fungicidal imidazole derivatives E. I. DU PONT DE NEMOURS AND COMPANY (US) 1985-01-29 US disclosed
EP-0068813-A2 Fungicidal 1,2,4-triazole and imidazole derivatives E.I. DU PONT DE NEMOURS AND COMPANY (US) 1983-01-05 EP disclosed