Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 4/20 | 0.77 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.59 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.70 |
| ▸ | MC4R | P32245 | 1/20 | 0.63 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.61 |
| ▸ | DRD4 | P21917 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | CASP1 | P29466 | 1/20 | 0.57 |
| ▸ | CASP5 | P51878 | 1/20 | 0.57 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.57 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10730905 | 0.98 | SIGMAR1 (0.74) | SIGMAR1HRH3MC4RHRH4DRD4 | |
| SCHEMBL13952 | 0.98 | SIGMAR1 (0.81) | SIGMAR1HRH3MC4RHRH4DRD4 | |
| SCHEMBL1777747 | 0.98 | SIGMAR1 (0.81) | SIGMAR1HRH3MC4RHRH4DRD4 | |
| SCHEMBL688047 | 0.95 | SIGMAR1 (0.77) | SIGMAR1HRH3MC4RHRH4DRD4 | |
| Ammonia Solution, Strong SCHEMBL3699405 | 0.95 | SIGMAR1 (0.77) | SIGMAR1HRH3MC4RHRH4DRD4 | |
| SCHEMBL26532 | 0.95 | SIGMAR1 (0.77) | SIGMAR1HRH3MC4RHRH4DRD4 | |
| SCHEMBL8327 | 0.95 | SIGMAR1 (0.77) | SIGMAR1HRH3MC4RHRH4DRD4 | |
| SCHEMBL11141692 | 0.95 | SIGMAR1 (0.77) | SIGMAR1HRH3MC4RHRH4DRD4 | |
| SCHEMBL11585348 | 0.95 | SIGMAR1 (0.77) | SIGMAR1HRH3MC4RHRH4DRD4 | |
| Hydrochloric Acid SCHEMBL7409551 | 0.93 | SIGMAR1 (0.74) | SIGMAR1HRH3MC4RHRH4DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0367130-A2 | Pyrrolidine derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-05-09 | — | — | EP | disclosed |