Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 7/20 | 0.68 |
| ▸ | CYP1B1 | Q16678 | 7/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.68 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.68 |
| ▸ | JUN | P05412 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.58 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.52 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1044981 | 1.00 | CYP1A1 (0.68) | CYP1A1CYP1B1CYP1A2NFE2L2JUN | |
| SCHEMBL1046769 | 0.85 | CYP1A2 (0.78) | CYP1A1CYP1B1CYP1A2NFE2L2CYP19A1 | |
| SCHEMBL1046770 | 0.85 | CYP1A2 (0.78) | CYP1A1CYP1B1CYP1A2NFE2L2CYP19A1 | |
| SCHEMBL11874684 | 0.84 | CYP1A1 (0.79) | CYP1A1CYP1B1CYP1A2NFE2L2JUN | |
| SCHEMBL11874692 | 0.84 | CYP1A1 (0.79) | CYP1A1CYP1B1CYP1A2NFE2L2JUN | |
| SCHEMBL7871043 | 0.82 | CYP1A1 (0.70) | CYP1A1CYP1B1CYP1A2NFE2L2JUN | |
| SCHEMBL265496 | 0.82 | CYP1A1 (0.70) | CYP1A1CYP1B1CYP1A2NFE2L2JUN | |
| SCHEMBL30474601 | 0.82 | CYP1A1 (0.70) | CYP1A1CYP1B1CYP1A2NFE2L2JUN | |
| SCHEMBL14224730 | 0.82 | CYP1A1 (0.70) | CYP1A1CYP1B1CYP1A2NFE2L2JUN | |
| SCHEMBL1824235 | 0.81 | CYP1A1 (0.68) | CYP1A1CYP1B1CYP1A2NFE2L2JUN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101362724-A | Tetramethylpyrazine acidamides derivates, preparation method and medicament composition and application | UNIV SHANDONG (CN) | 2009-02-11 | — | — | CN | claimed |
| EP-1227859-B1 | NEUROPHILIN LIGANDS FOR TREATING OCULAR CONDITIONS | ALCON INC (CH) | 2006-08-09 | — | — | EP | claimed |
| US-6943187-B2 | Pyrrolidine derivative hair growth compositions and uses | GPI NIL HOLDINGS, INC. (US) | 2005-09-13 | — | — | US | claimed |
| US-20040186098-A1 | Method for preventing and treating hearing loss using sensorineurotrophic compounds | AMGEN INC. | 2004-09-23 | — | — | US | claimed |
| EP-1404325-A2 | METHOD FOR TREATING NERVE INJURY CAUSED BY SURGERY | GUILFORD PHARMACEUTICALS INC. (US) | 2004-04-07 | — | — | EP | claimed |
| US-20040049046-A1 | Small molecule inhibitors of rotamase enzyme activity | GPI NIL HOLDINGS, INC. (US) | 2004-03-11 | — | — | US | claimed |
| US-20030203890-A1 | Method for treating nerve injury caused as a result of surgery | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2003-10-30 | — | — | US | claimed |
| WO-2002096420-A2 | METHOD FOR TREATING NERVE INJURY CAUSED BY SURGERY | GUILFORD PHARMACEUTICALS INC. (US) | 2002-12-05 | — | — | WO | claimed |
| JP-2002510302-A | — | — | 2002-04-02 | — | — | JP | claimed |
| US-20010049381-A1 | Pyrrolidine derivative hair growth compositions and uses | GPL NIL HOLDINGS, INC., | 2001-12-06 | — | — | US | claimed |
| US-6177455-B1 | ADMINISTERING A NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | GPI NIL HOLDINGS, INC. | 2001-01-23 | — | — | US | claimed |
| EP-0769006-B1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GUILFORD PHARM INC (US) | 2000-11-08 | — | — | EP | claimed |
| EP-1011650-A1 | METHOD FOR PREVENTING AND TREATING HEARING LOSS USING SENSORINEUROTROPHIC COMPOUNDS | Amgen Inc., (US) | 2000-06-28 | — | — | EP | claimed |
| EP-0998263-A1 | PYRROLIDINE DERIVATIVE HAIR GROWTH COMPOSITIONS AND USES | GUILFORD PHARMACEUTICALS INC. (US) | 2000-05-10 | — | — | EP | claimed |
| EP-0992492-A1 | Small molecule inhibitors of rotamase enzyme activity | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-12 | — | — | EP | claimed |
| WO-2000009124-A1 | PYRROLIDINE DERIVATIVES FOR VISION AND MEMORY DISORDERS | GPI NIL HOLDINGS, INC. (US) | 2000-02-24 | — | — | WO | claimed |
| WO-1999014998-A2 | METHOD FOR PREVENTING AND TREATING HEARING LOSS USING SENSORINEUROTROPHIC COMPOUNDS | AMGEN INC. (US) | 1999-04-01 | — | — | WO | claimed |
| US-5859031-A | Small molecule inhibitors of rotamase enzyme activity | GPI NIL HOLDINGS, INC. (US) | 1999-01-12 | — | — | US | claimed |
| WO-1998055091-A1 | PYRROLIDINE DERIVATIVE HAIR GROWTH COMPOSITIONS AND USES | GUILFORD PHARMACEUTICALS INC. (US) | 1998-12-10 | — | — | WO | claimed |
| WO-1996040633-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1996-12-19 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040186098-A1 | Method for preventing and treating hearing loss using sensorineurotrophic compounds | GAP43, CHAT, MYOC | CYP1A1 4605/4885CYP1B1 4372/4885CYP1A2 4589/4885 |
| US-20030203890-A1 | Method for treating nerve injury caused as a result of surgery | NGF, BDNF, GAP43 | CYP1A1 4091/4885CYP1B1 3581/4885CYP1A2 3201/4885 |
| US-20040049046-A1 | Small molecule inhibitors of rotamase enzyme activity | FKBP8, FKBP14, PREP | CYP1A1 3601/4885CYP1B1 2968/4885CYP1A2 3870/4885 |
| US-20010049381-A1 | Pyrrolidine derivative hair growth compositions and uses | MKI67, PLOD2, HDGF | CYP1A1 1114/4885CYP1B1 623/4885CYP1A2 501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.