Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 5/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | TTR | P02766 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10453856 | 0.92 | HCRTR1 (0.51) | CASP3SENP7SENP6MAOACYP3A4 | |
| SCHEMBL11614996 | 0.90 | CASP3 (0.40) | CASP3SENP7SENP6MAOACYP3A4 | |
| SCHEMBL11632376 | 0.84 | ALDH1A1 (0.53) | CASP3SENP7SENP6MAOACYP3A4 | |
| SCHEMBL11629271 | 0.83 | MKNK2 (0.36) | CASP3SENP7SENP6MAOACYP3A4 | |
| SCHEMBL10454186 | 0.82 | RAB9A (0.54) | CASP3SENP7SENP6MAOAHSD17B10 | |
| SCHEMBL10452829 | 0.82 | KDM4E (0.61) | CASP3SENP7SENP6MAOACYP3A4 | |
| SCHEMBL10454114 | 0.82 | MAOA (0.51) | CASP3SENP7SENP6MAOACYP3A4 | |
| SCHEMBL11633567 | 0.80 | TBK1 (0.44) | CASP3SENP7SENP6KDM4EALDH1A1 | |
| SCHEMBL11367792 | 0.80 | KDM4E (0.41) | CASP3SENP7SENP6MAOACYP3A4 | |
| SCHEMBL10454174 | 0.79 | HCRTR1 (0.37) | CASP3SENP7SENP6MAOAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4902701-A | Tetrazolyl substituted tricyclic compounds and pharmacological compositions thereof | BURROUGHS WELCOME CO. (US) | 1990-02-20 | — | — | US | disclosed |
| EP-0093381-A1 | Tricyclic compounds, preparation, use and intermediates | THE WELLCOME FOUNDATION LIMITED (GB) | 1983-11-09 | — | — | EP | disclosed |