Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 7/20 | 0.81 |
| ▸ | CA1 | P00915 | 2/20 | 0.81 |
| ▸ | CA9 | Q16790 | 2/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.73 |
| ▸ | MITF | O75030 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 4/20 | 0.69 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.68 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 3/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.63 |
| ▸ | ALPL | P05186 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10480438 | 0.87 | LMNA (0.72) | GAACA1CA9ALDH1A1MITF | |
| SCHEMBL10480374 | 0.85 | GAA (0.61) | GAACA1CA9ALDH1A1MITF | |
| SCHEMBL14096444 | 0.85 | ALDH1A1 (1.00) | ALDH1A1MITFLMNAMEN1KMT2A | |
| SCHEMBL9354722 | 0.83 | TP53 (0.72) | GAACA1CA9ALDH1A1MITF | |
| SCHEMBL11374387 | 0.83 | ALDH1A1 (0.69) | GAACA1CA9ALDH1A1MITF | |
| SCHEMBL11298577 | 0.82 | RAB9A (0.75) | GAACA1CA9ALDH1A1MEN1 | |
| SCHEMBL31558731 | 0.81 | KMT2A (0.72) | GAACA1CA9ALDH1A1LMNA | |
| SCHEMBL457082 | 0.80 | HDAC6 (0.79) | GAAALDH1A1MITFLMNAHPGD | |
| SCHEMBL3917581 | 0.79 | GAA (0.68) | GAACA1CA9ALDH1A1LMNA | |
| SCHEMBL10480368 | 0.79 | GAA (0.54) | GAACA1CA9ALDH1A1MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1989006125-A1 | 4-ARALKYL-5-SUBSTITUTED-1,2,4-TRIAZOLE-5-THIOLS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-07-13 | — | — | WO | disclosed |
| EP-0323737-A1 | 4-Aralkyl-5-substituted-1,2,4-triazole-5-thiols | SMITHKLINE BEECHAM CORPORATION (US) | 1989-07-12 | — | — | EP | disclosed |