Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10483438 | 0.87 | NPC1 (0.40) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL10483371 | 0.87 | JAK2 (0.41) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL10483546 | 0.83 | LMNA (0.45) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL9566459 | 0.82 | JAK2 (0.45) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL9566410 | 0.82 | HDAC1 (0.42) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL10483353 | 0.82 | SIRT2 (0.55) | SIRT2KDM4ENPC1RAB9AMEN1 | |
| SCHEMBL9566552 | 0.81 | GABRP (0.48) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL9566514 | 0.79 | CSNK1D (0.45) | HDAC1HDAC2KLKB1KDM4EMAPT | |
| SCHEMBL10822461 | 0.77 | MEN1 (0.44) | HDAC1KDM4EMAPTNPC1RAB9A | |
| SCHEMBL10483488 | 0.76 | L3MBTL1 (0.45) | HDAC8KDM4EMAPTGABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4874762-A | TREATING DEMENTIA | NIPPON SHINYAKU CO., LTD. (JP) | 1989-10-17 | — | — | US | claimed |
| US-4874762-A | TREATING DEMENTIA | NIPPON SHINYAKU CO., LTD. (JP) | 1989-10-17 | — | — | US | disclosed |
| US-4593025-A | A 2-naphthyl-4,6-diamino-s-triazine compound | NIPPON SHINYAKU CO., LTD. (JP) | 1986-06-03 | — | — | US | disclosed |
| US-4554275-A | Triazine derivatives | NIPPON SHINYAKU CO., LTD. (JP) | 1985-11-19 | — | — | US | disclosed |