Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10483371 | 0.89 | JAK2 (0.41) | JAK2TYK2NPC1RAB9AKMT2A | |
| SCHEMBL10483488 | 0.87 | L3MBTL1 (0.45) | JAK2TYK2NPC1RAB9AKMT2A | |
| SCHEMBL9566580 | 0.87 | L3MBTL1 (0.42) | JAK2TYK2NPC1RAB9AKMT2A | |
| SCHEMBL9566563 | 0.87 | TYK2 (0.49) | JAK2TYK2NPC1RAB9AKMT2A | |
| SCHEMBL9566410 | 0.86 | HDAC1 (0.42) | NPC1RAB9AKMT2AMEN1HDAC1 | |
| SCHEMBL10483546 | 0.85 | LMNA (0.45) | NPC1RAB9AKMT2AMEN1HDAC1 | |
| SCHEMBL9566552 | 0.83 | GABRP (0.48) | NPC1RAB9AKMT2AMEN1GSK3A | |
| SCHEMBL10483372 | 0.82 | HDAC1 (0.41) | NPC1RAB9AKMT2AMEN1HDAC1 | |
| SCHEMBL10483438 | 0.82 | NPC1 (0.40) | NPC1RAB9AKMT2AMEN1HDAC1 | |
| SCHEMBL9566616 | 0.81 | ALDH1A1 (0.46) | JAK2TYK2NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4874762-A | TREATING DEMENTIA | NIPPON SHINYAKU CO., LTD. (JP) | 1989-10-17 | — | — | US | claimed |
| EP-0563386-A1 | ANTICANCER COMPOSITION AND COMPOUND | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1993-10-06 | — | — | EP | disclosed |
| US-4874762-A | TREATING DEMENTIA | NIPPON SHINYAKU CO., LTD. (JP) | 1989-10-17 | — | — | US | disclosed |