Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 1/20 | 0.48 |
| ▸ | GABRD | O14764 | 1/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.48 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.48 |
| ▸ | GABRE | P78334 | 1/20 | 0.48 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.48 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.48 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.48 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10483353 | 0.88 | SIRT2 (0.55) | SIRT2KDM4ENPC1RAB9ATP53 | |
| SCHEMBL9566461 | 0.88 | L3MBTL1 (0.49) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL9566514 | 0.88 | CSNK1D (0.45) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL9566634 | 0.87 | ADORA1 (0.48) | ADORA1ADORA3CDK5CDK5R1KDM4E | |
| SCHEMBL9566616 | 0.83 | ALDH1A1 (0.46) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL9566410 | 0.83 | HDAC1 (0.42) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL9566459 | 0.83 | JAK2 (0.45) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL10483546 | 0.82 | LMNA (0.45) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL9566563 | 0.81 | TYK2 (0.49) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL10483372 | 0.81 | HDAC1 (0.41) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4874762-A | TREATING DEMENTIA | NIPPON SHINYAKU CO., LTD. (JP) | 1989-10-17 | — | — | US | claimed |
| EP-0563386-A1 | ANTICANCER COMPOSITION AND COMPOUND | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1993-10-06 | — | — | EP | disclosed |
| US-4874762-A | TREATING DEMENTIA | NIPPON SHINYAKU CO., LTD. (JP) | 1989-10-17 | — | — | US | disclosed |