Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 10/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TPH1 | P17752 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9566552 | 0.88 | GABRP (0.48) | SIRT2NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL9566616 | 0.84 | ALDH1A1 (0.46) | NPC1RAB9AKDM4EMEN1KMT2A | |
| SCHEMBL9566461 | 0.83 | L3MBTL1 (0.49) | NPC1RAB9AMEN1KMT2ADEGS1 | |
| SCHEMBL9566514 | 0.83 | CSNK1D (0.45) | KDM4EGSK3B | |
| SCHEMBL9566634 | 0.83 | ADORA1 (0.48) | KDM4EMEN1KMT2AHTT | |
| SCHEMBL10483438 | 0.82 | NPC1 (0.40) | SIRT2NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL10483372 | 0.82 | HDAC1 (0.41) | SIRT2NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL9566531 | 0.82 | HDAC1 (0.48) | NPC1RAB9AMEN1KMT2AHTT | |
| SCHEMBL10483371 | 0.82 | JAK2 (0.41) | SIRT2NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL10483546 | 0.81 | LMNA (0.45) | SIRT2NPC1RAB9AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4874762-A | TREATING DEMENTIA | NIPPON SHINYAKU CO., LTD. (JP) | 1989-10-17 | — | — | US | claimed |
| US-4874762-A | TREATING DEMENTIA | NIPPON SHINYAKU CO., LTD. (JP) | 1989-10-17 | — | — | US | disclosed |