Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 2/20 | 0.37 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5917114 | 0.74 | HTR1D (0.62) | HTR1DNR2E1 | |
| SCHEMBL8670950 | 0.72 | GRIA1 (0.43) | PLAUNR2E1 | |
| SCHEMBL30955211 | 0.72 | KIF11 (0.39) | HTR1D | |
| SCHEMBL4823203 | 0.72 | KIF11 (0.39) | HTR1D | |
| SCHEMBL4821008 | 0.72 | KIF11 (0.42) | HTR1D | |
| SCHEMBL10487277 | 0.68 | DRD3 (0.56) | PLAUDRD2DRD3ADRA1AOPRK1 | |
| SCHEMBL30559735 | 0.67 | TNF (0.36) | — | |
| SCHEMBL6100296 | 0.67 | ADRA2A (0.42) | DRD2DRD3ADRA1A | |
| SCHEMBL10487293 | 0.66 | LMNA (0.44) | PLAUDRD2DRD3ADRA1AOPRK1 | |
| SCHEMBL20541880 | 0.65 | PLAU (0.48) | PLAUDRD2DRD3OPRK1NR2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4885373-A | AMINE DERVIVATIVES USED AS ANTIDEPRESSANT AND DOPAMINERGIC STIMULANTS | ADIR ET CIE (FR) | 1989-12-05 | — | — | US | disclosed |
| US-4874878-A | CHEMICAL INTERMEDIATES FOR ANTIDEPRESSANTS | ADIR ET CIE (FR) | 1989-10-17 | — | — | US | disclosed |
| US-4863951-A | ANTIDEPRESSANTS, ANTIAGRESSIVES, DOPAMINERGIC PROPERTIES | ADIR ET CIE (FR) | 1989-09-05 | — | — | US | disclosed |
| US-4851429-A | ANTIDEPRESSANT, TRANQUILIZERS | ADIR ET CIE (FR) | 1989-07-25 | — | — | US | disclosed |
| US-4510157-A | 6,7,8,9-Tetrahydro-1H-benz(g)indol-8-amine derivatives | AYERST, MCKENNA & HARRISON, INC. (CA) | 1985-04-09 | — | — | US | disclosed |
| US-4510157-A | 6,7,8,9-Tetrahydro-1H-benz(g)indol-8-amine derivatives | AYERST, MCKENNA & HARRISON, INC. (CA) | 1985-04-09 | — | — | US | disclosed |