Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.44 |
| ▸ | MLYCD | O95822 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9763439 | 1.00 | THRA (0.49) | THRATHRBALDH1A1MAPTNPC1 | |
| SCHEMBL9763048 | 0.87 | THRA (0.47) | THRATHRBALDH1A1HPGDSPHK1 | |
| SCHEMBL10488209 | 0.85 | THRA (0.45) | THRATHRBALDH1A1HPGDSPHK1 | |
| SCHEMBL10488170 | 0.84 | LMNA (0.51) | ALDH1A1NPC1LMNARAB9AHPGD | |
| SCHEMBL9760957 | 0.83 | THRA (0.49) | THRATHRBALDH1A1MAPTNPC1 | |
| SCHEMBL9796685 | 0.83 | ALDH1A1 (0.47) | THRATHRBALDH1A1MAPTNPC1 | |
| SCHEMBL9796936 | 0.81 | ALDH1A1 (0.47) | THRATHRBALDH1A1MAPTNPC1 | |
| SCHEMBL2399439 | 0.81 | THRA (0.61) | THRATHRBALDH1A1MAPTMEN1 | |
| SCHEMBL3185726 | 0.81 | THRA (0.61) | THRATHRBALDH1A1MAPTMEN1 | |
| SCHEMBL9763616 | 0.80 | HRH3 (0.39) | ALDH1A1MAPTNPC1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4853382-A | TREATING ASTHMA AND BRONCHITIS | GLAXO GROUP LIMITED (GB) | 1989-08-01 | — | — | US | disclosed |
| US-4730008-A | STIMULANT FOR BETA-ADRENORECEPTORS | GLAXO GROUP LIMITED (GB) | 1988-03-08 | — | — | US | disclosed |