Sugi Predict

Sugi Predict / Compounds / SCHEMBL10496

SCHEMBL10496

SCHEMBL10496

CCCC(=O)NCCOC

nearest known ligand 0.59

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 1/20 0.59
▸ CNR1 P21554 1/20 0.57
▸ CASP2 P42575 1/20 0.55
▸ HPGD P15428 2/20 0.47
▸ SMN1; SMN2 Q16637 2/20 0.47
▸ HTT P42858 1/20 0.47
▸ ALDH1A1 P00352 1/20 0.47
▸ TDP1 Q9NUW8 1/20 0.47
▸ KDM4E B2RXH2 2/20 0.46
▸ GLA P06280 1/20 0.46
▸ L3MBTL1 Q9Y468 1/20 0.46
▸ HDAC3 O15379 1/20 0.44
▸ HDAC1 Q13547 1/20 0.44
▸ HDAC2 Q92769 1/20 0.44
▸ HDAC8 Q9BY41 1/20 0.44
▸ HDAC6 Q9UBN7 1/20 0.44
▸ LMNA P02545 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23478140 0.89 TSHR (0.65) TSHRCNR1HPGDSMN1; SMN2HTT
SCHEMBL29686983 0.88 TSHR (0.52) TSHRCNR1CASP2HPGDSMN1; SMN2
SCHEMBL16365459 0.88 TSHR (0.52) TSHRCNR1CASP2HPGDSMN1; SMN2
SCHEMBL17888017 0.88 TSHR (0.52) TSHRCNR1CASP2HPGDSMN1; SMN2
SCHEMBL12245392 0.88 TSHR (0.78) TSHRCNR1CASP2HPGDALDH1A1
SCHEMBL13501556 0.88 CNR1 (0.67) TSHRCNR1CASP2HPGDSMN1; SMN2
SCHEMBL7323180 0.86 CNR1 (0.69) TSHRCNR1CASP2HPGDSMN1; SMN2
SCHEMBL8353728 0.86 TSHR (0.69) TSHRCNR1CASP2HPGDALDH1A1
SCHEMBL16203711 0.85 TSHR (0.58) TSHRCNR1CASP2HPGDSMN1; SMN2
SCHEMBL6652097 0.84 CNR1 (0.68) TSHRCNR1CASP2HPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105408306-A Resorcinol derivatives and cosmetic use thereof OREAL 2016-03-16 — — CN claimed
CN-118255685-A Tricyclic compound, pharmaceutical composition and application thereof 珂阑(上海)医药科技有限公司 2024-06-28 — — CN disclosed
WO-2024112918-A1 RNA DEGRADERS AND USES THEREOF ARRAKIS THERAPEUTICS, INC. (US) 2024-05-30 — — WO disclosed
US-20230323028-A1 ADHESIVE PHOTOPROTECTIVE COMPOUNDS AND USES THEREOF SKINOSIVE (FR) 2023-10-12 — — US disclosed
US-20230323028-A1 ADHESIVE PHOTOPROTECTIVE COMPOUNDS AND USES THEREOF SKINOSIVE (FR) 2023-10-12 — — US disclosed
US-20230183184-A1 3-(Carboxyethyl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives GRUENENTHAL GMBH (DE) 2023-06-15 — — US disclosed
WO-2021123116-A1 ADHESIVE PHOTOPROTECTIVE COMPOUNDS AND USES THEREOF SKINOSIVE (FR) 2021-06-24 — — WO disclosed
EP-3652157-B1 1,3-DIAZA-SPIRO-[3.4]-OCTANE DERIVATIVES GRUENENTHAL GMBH (DE) 2021-05-05 — — EP disclosed
US-20210094950-A1 KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE NATIONAL INSTITUTES OF HEALTH 2021-04-01 — — US disclosed
WO-2021000925-A1 PYRROLO [2, 3-b] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF BEIGENE, LTD. (KY) 2021-01-07 — — WO disclosed
US-6924342-B2 Method of making interpolymers and products made therefrom DOW GLOBAL TECHNOLOGIES INC. (US) 2005-08-02 — — US disclosed
US-20050065286-A1 High melt strength polymers and method of making same DOW GLOBAL TECHNOLOGIES LLC 2005-03-24 — — US disclosed
US-20050020778-A1 High melt strength polymers and method of making same DOW GLOBAL TECHNOLOGIES LLC 2005-01-27 — — US disclosed
EP-1412398-A2 HIGH MELT STRENGTH POLYMERS AND METHOD OF MAKING SAME DOW GLOBAL TECHNOLOGIES INC. (US) 2004-04-28 — — EP disclosed
EP-1377613-A2 METHOD OF MAKING INTERPOLYMERS AND PRODUCTS MADE THEREFROM DOW GLOBAL TECHNOLOGIES INC. (US) 2004-01-07 — — EP disclosed
US-20030088037-A1 Method of making interpolymers and products made therefrom THE DOW CHEMICAL COMPANY (US) 2003-05-08 — — US disclosed
WO-2002100906-A1 USE OF POLAR MONOMERS IN OLEFIN POLYMERIZATION AND POLYMERS THEREOF DOW GLOBAL TECHNOLOGIES INC. (US) 2002-12-19 — — WO disclosed
WO-2002074817-A2 METHOD OF MAKING INTERPOLYMERS AND PRODUCTS MADE THEREFROM DOW GLOBAL TECHNOLOGIES INC. (US) 2002-09-26 — — WO disclosed
WO-2002074816-A2 HIGH MELT STRENGTH POLYMERS AND METHOD OF MAKING SAME DOW GLOBAL TECHNOLOGIES INC. (US) 2002-09-26 — — WO disclosed
WO-1997026287-A9 ULTRA-LOW MOLECULAR WEIGHT ETHYLENE POLYMERS — 1997-10-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230323028-A1 ADHESIVE PHOTOPROTECTIVE COMPOUNDS AND USES THEREOF ICAM1, CDH1, VCAM1 TSHR 4772/4885CNR1 4251/4885CASP2 2925/4885
US-20230183184-A1 3-(Carboxyethyl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives OPRK1, OPRD1, PKD2 TSHR 2512/4885CNR1 12/4885CASP2 1083/4885
US-20210094950-A1 KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE CSNK1A1, CSNK1E, CSNK1G3 TSHR 679/4885CNR1 552/4885CASP2 3501/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.