Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | FBP1 | P09467 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10501567 | 0.84 | ALDH1A1 (0.38) | KDM4EMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL10502269 | 0.83 | MAPT (0.33) | KDM4EMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL10501573 | 0.83 | MAPT (0.33) | KDM4EMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL10501085 | 0.78 | MAPT (0.33) | KDM4EMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL10501096 | 0.78 | KDM4E (0.34) | KDM4EMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL10501841 | 0.77 | KDM4E (0.41) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL10749778 | 0.76 | — | — | |
| SCHEMBL10501953 | 0.75 | MEN1 (0.32) | KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL10501689 | 0.75 | FBP1 (0.35) | KDM4EALDH1A1FBP1 | |
| SCHEMBL10501622 | 0.75 | RAB9A (0.43) | KDM4EMEN1NPC1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154851-B1 | BENZISOSELENAZOLETHIONES,PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PRODUCTS CONTAINING THESE COMPOUNDS | A. Nattermann & Cie. GmbH (DE) | 1989-08-02 | — | — | EP | disclosed |
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |
| EP-0154851-A1 | Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-18 | — | — | EP | disclosed |