Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 2/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 5/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.47 |
| ▸ | F2 | P00734 | 3/20 | 0.47 |
| ▸ | PLAU | P00749 | 6/20 | 0.47 |
| ▸ | HPN | P05981 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MASP2 | O00187 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.46 |
| ▸ | C1S | P09871 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 4-Methylbenzimidamide SCHEMBL15844882 | 0.98 | NQO2 (0.50) | NQO2PRSS1PRSS3PRSS2F2 | |
| 4-Methylbenzimidamide SCHEMBL524027 | 0.87 | LMNA (0.59) | NQO2PRSS1PRSS3PRSS2F2 | |
| 4-Methylbenzimidamide SCHEMBL1019464 | 0.84 | PRSS1 (0.61) | NQO2PRSS1PRSS3PRSS2F2 | |
| 4-Methylbenzimidamide SCHEMBL28504756 | 0.84 | PRSS1 (0.61) | NQO2PRSS1PRSS3PRSS2F2 | |
| SCHEMBL8558497 | 0.84 | GAA (0.61) | NQO2PRSS1PRSS3PRSS2F2 | |
| SCHEMBL8127463 | 0.82 | CYP2D6 (0.55) | NQO2PRSS1PRSS3PRSS2F2 | |
| 4-Methylbenzimidamide SCHEMBL1436204 | 0.82 | LMNA (0.54) | NQO2PRSS1PRSS3PRSS2F2 | |
| 4-Methylbenzimidamide SCHEMBL28496422 | 0.82 | PRSS1 (0.58) | NQO2PRSS1PRSS3PRSS2F2 | |
| SCHEMBL12461484 | 0.80 | WDR5 (0.64) | NQO2PRSS1PRSS3PRSS2F2 | |
| SCHEMBL9029471 | 0.78 | HPN (0.50) | NQO2PRSS1PRSS3PRSS2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7867699-B2 | Method of synthesizing and purifying Dkk proteins and Dkk proteins obtained thereby | WYETH (US) | 2011-01-11 | — | — | US | disclosed |
| US-20060035827-A1 | Compositions and methods for the treatment or prevention of gallbladder disease | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2006-02-16 | — | — | US | disclosed |
| WO-2005095448-A2 | METHOD OF SYNTHESIZING AND PURIFYING DKK PROTEINS AND DKK PROTEINS OBTAINED THEREBY | OSCIENT PHARMACEUTICALS CORPORATION (US) | 2005-10-13 | — | — | WO | disclosed |
| US-5324648-A | Anticoagulants; antitumor agents | GEORGIA TECH RESEARCH CORPORATION (US) | 1994-06-28 | — | — | US | disclosed |
| US-5120715-A | Treating with crosslinked cellulose or agarose sulfate | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-06-09 | — | — | US | disclosed |
| US-4954519-A | Isocoumarins with basic substituents as serine proteases inhibitors, anticoagulants and anti-inflammatory agents | GEORGIA TECH RESEARCH CORPORATION (US) | 1990-09-04 | — | — | US | disclosed |
| EP-0373540-A2 | Method for purifying fibroblast growth factor protein | Takeda Chemical Industries, Ltd. (JP) | 1990-06-20 | — | — | EP | disclosed |
| WO-1990002175-A1 | A METHOD OF PRODUCING POLYPEPTIDES BY CULTURING EUKARYOTIC CELLS IN THE PRESENCE OF PROTEASE INHIBITORS | NOVO NORDISK A/S (DK) | 1990-03-08 | — | — | WO | disclosed |
| US-4845242-A | ANTITUMOR | GEORGIA TECH RESEARCH CORPORATION (US) | 1989-07-04 | — | — | US | disclosed |
| EP-0301458-A2 | Composition containing a peptide fragment of platelet factor four and method for restoring suppressed immune responses | NEW YORK UNIVERSITY (US) | 1989-02-01 | — | — | EP | disclosed |