Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of 4-Methylbenzimidamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 7/20 | 0.61 |
| ▸ | PRSS3 | P35030 | 6/20 | 0.61 |
| ▸ | F2 | P00734 | 3/20 | 0.61 |
| ▸ | APEX1 | P27695 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | PLAU | P00749 | 2/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | MASP2 | O00187 | 1/20 | 0.56 |
| ▸ | THPO | P40225 | 1/20 | 0.56 |
| ▸ | NOS3 | P29474 | 1/20 | 0.56 |
| ▸ | NOS1 | P29475 | 1/20 | 0.56 |
| ▸ | NOS2 | P35228 | 1/20 | 0.56 |
| ▸ | NQO2 | P16083 | 2/20 | 0.55 |
| ▸ | PRSS2 | P07478 | 5/20 | 0.54 |
| ▸ | C1S | P09871 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | F10 | P00742 | 2/20 | 0.52 |
| ▸ | F12 | P00748 | 1/20 | 0.52 |
| ▸ | F7 | P08709 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 4-Methylbenzimidamide SCHEMBL28504756 | 1.00 | PRSS1 (0.61) | PRSS1PRSS3F2APEX1LMNA | |
| 4-Methylbenzimidamide SCHEMBL28496422 | 0.97 | PRSS1 (0.58) | PRSS1PRSS3F2APEX1LMNA | |
| 4-Methylbenzimidamide SCHEMBL524027 | 0.97 | LMNA (0.59) | PRSS1PRSS3F2APEX1LMNA | |
| 4-Methylbenzimidamide SCHEMBL1436204 | 0.92 | LMNA (0.54) | PRSS1PRSS3F2APEX1LMNA | |
| 4-Methylbenzimidamide SCHEMBL28399173 | 0.91 | BLM (0.74) | PRSS1PRSS3F2APEX1LMNA | |
| SCHEMBL12461484 | 0.90 | WDR5 (0.64) | PRSS1PRSS3F2APEX1LMNA | |
| 4-Methylbenzimidamide SCHEMBL15844882 | 0.87 | NQO2 (0.50) | PRSS1PRSS3F2APEX1LMNA | |
| Hydrochloric Acid SCHEMBL392375 | 0.86 | PRSS1 (0.78) | PRSS1PRSS3F2APEX1LMNA | |
| Hydrochloric Acid SCHEMBL30999366 | 0.86 | PRSS1 (0.78) | PRSS1PRSS3F2APEX1LMNA | |
| SCHEMBL20364177 | 0.84 | ST14 (0.79) | PRSS1PRSS3F2PLAUPRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 170 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117003738-A | Imidazole spiro compound and synthesis method thereof | 湘潭大学 | 2023-11-07 | — | — | CN | claimed |
| CN-116947854-A | Preparation method of imidazo [2,1-a ] isoquinoline compound | 赣南师范大学 | 2023-10-27 | — | — | CN | claimed |
| CN-114853681-A | Preparation method of pyrimidine heterocyclic guanyl formate compound | 南京工业大学 | 2022-08-05 | — | — | CN | claimed |
| CN-113024470-B | 4-perfluoroalkyl substituted pyrimidine compound and preparation method and application thereof | 南京工业大学 | 2022-05-24 | — | — | CN | claimed |
| CN-113024470-A | 4-perfluoroalkyl substituted pyrimidine compound and preparation method and application thereof | 南京工业大学 | 2021-06-25 | — | — | CN | claimed |
| CN-112159411-A | Trifluoromethyl substituted pyrimido [1,3] diaza compound and preparation method thereof | 南京工业大学 | 2021-01-01 | — | — | CN | claimed |
| CN-104177298-B | Bis- substitution -4,5- dihydros -1H of 4,4--imidazoles -5- ketone, derivative and its synthetic method | 湘潭大学 | 2018-10-02 | — | — | CN | claimed |
| CN-106946808-A | The synthetic method of benzo [1,3,5] triazole octanone derivative | 苏州大学 | 2017-07-14 | — | — | CN | claimed |
| CN-119874625-A | Synthesis method of pyrimidine compound promoted by visible light | 南通大学 | 2025-04-25 | — | — | CN | disclosed |
| CN-119118995-A | Phenyl diphenyl pyrimidine compound and organic electroluminescent device thereof | 昱镭光电科技股份有限公司 | 2024-12-13 | — | — | CN | disclosed |
| CN-118086928-A | Method for electrochemical synthesis of pyrimidoindole derivative under mild condition | 湘潭大学 | 2024-05-28 | — | — | CN | disclosed |
| CN-117209508-A | Azaphenothiazine compound and preparation method thereof | 五邑大学 | 2023-12-12 | — | — | CN | disclosed |
| CN-117003738-A | Imidazole spiro compound and synthesis method thereof | 湘潭大学 | 2023-11-07 | — | — | CN | disclosed |
| CN-116947854-A | Preparation method of imidazo [2,1-a ] isoquinoline compound | 赣南师范大学 | 2023-10-27 | — | — | CN | disclosed |
| US-4297234-A | OPTICAL BRIGHTENERS | CIBA-GEIGY CORPORATION (US) | 1981-10-27 | — | — | US | disclosed |
| EP-0031796-A2 | 4-Heterocyclyl-4'-vinyl-stilbenes | CIBA-GEIGY AG (CH) | 1981-07-08 | — | — | EP | disclosed |
| EP-0020298-A1 | Benzoxazolyl stilbenes, process for their preparation and their use as optical brighteners for organic materials | CIBA-GEIGY AG (CH) | 1980-12-10 | — | — | EP | disclosed |
| US-3968213-A | 4-HYDROXY-5-CARBOXY PYRIMIDINES | PFIZER INC. (US) | 1976-07-06 | — | — | US | disclosed |
| US-3957784-A | ANTIALLERGY AGENTS | PFIZER INC. (US) | 1976-05-18 | — | — | US | disclosed |
| US-3940395-A | CNS DEPRESSANT | AMERICAN HOME PRODUCTS CORPORATION (US) | 1976-02-24 | — | — | US | disclosed |