Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 12/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 10/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10504827 | 0.88 | HTR1A (0.48) | HTR1AUSP2CYP1A2ADRA2ACYP2D6 | |
| SCHEMBL10505569 | 0.88 | HTR1A (0.57) | HTR1AUSP2CYP1A2ADRA2ACYP2D6 | |
| SCHEMBL10505526 | 0.87 | HTR1A (0.46) | HTR1AUSP2CYP1A2ADRA2ACYP2D6 | |
| SCHEMBL10503528 | 0.82 | ADRB2 (0.47) | HTR1ACYP1A2CYP2D6SLC6A4ADRA1A | |
| SCHEMBL10503675 | 0.81 | ADRB2 (0.58) | HTR1ACYP1A2CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL10504922 | 0.78 | ADRB1 (0.46) | HTR1ADRD3ADRB2ADRB1ADRB3 | |
| SCHEMBL10503765 | 0.77 | ADRB3 (0.40) | HTR1AADRA2ADRD1SLC6A2SLC6A4 | |
| SCHEMBL10504024 | 0.76 | ADRB2 (0.41) | ADRB2ADRB1ADRB3 | |
| SCHEMBL10505284 | 0.76 | ADRB1 (0.55) | HTR1AADRB2ADRB1ADRB3 | |
| SCHEMBL10504002 | 0.76 | ADRB3 (0.56) | HTR1AADRA2ADRD1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0200915-B1 | AMINOPROPANOL DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AND MEDICINES CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1989-09-27 | — | — | EP | disclosed |
| US-4863949-A | CARDIOVASCULAR DISORDER TREATMENT | BOEHRINGER MANNHEIM GMBH (DE) | 1989-09-05 | — | — | US | disclosed |
| EP-0200915-A1 | Aminopropanol derivatives, process for their preparation, their use and medicines containing them | Roche Diagnostics GmbH (DE) | 1986-11-12 | — | — | EP | disclosed |