Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 16/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 8/20 | 0.47 |
| ▸ | HTR1A | P08908 | 5/20 | 0.47 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10503675 | 0.91 | ADRB2 (0.58) | ADRB2ADRB1HTR1ALMNACYP1A2 | |
| SCHEMBL10593339 | 0.87 | ADRB2 (0.47) | ADRB2ADRB1HTR1ASLC22A1LMNA | |
| SCHEMBL10505246 | 0.82 | HTR1A (0.48) | ADRB2ADRB1HTR1ACYP1A2CYP2D6 | |
| SCHEMBL10504922 | 0.79 | ADRB1 (0.46) | ADRB2ADRB1HTR1A | |
| SCHEMBL10503765 | 0.79 | ADRB3 (0.40) | ADRB2ADRB1HTR1ASLC22A1LMNA | |
| SCHEMBL11809319 | 0.79 | ADRB2 (0.71) | ADRB2ADRB1HTR1ASLC22A1LMNA | |
| SCHEMBL10504326 | 0.78 | ADRB2 (0.51) | ADRB2ADRB1HTR1ALMNACYP1A2 | |
| SCHEMBL10865569 | 0.78 | ADRB2 (0.55) | ADRB2ADRB1HTR1ALMNACYP1A2 | |
| SCHEMBL10504002 | 0.78 | ADRB3 (0.56) | ADRB2ADRB1HTR1ASLC22A1LMNA | |
| SCHEMBL10503927 | 0.78 | ADRB3 (0.51) | ADRB2ADRB1HTR1ALMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0200915-B1 | AMINOPROPANOL DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AND MEDICINES CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1989-09-27 | — | — | EP | disclosed |
| US-4863949-A | CARDIOVASCULAR DISORDER TREATMENT | BOEHRINGER MANNHEIM GMBH (DE) | 1989-09-05 | — | — | US | disclosed |
| EP-0200915-A1 | Aminopropanol derivatives, process for their preparation, their use and medicines containing them | Roche Diagnostics GmbH (DE) | 1986-11-12 | — | — | EP | disclosed |