Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPYD | Q12882 | 4/20 | 0.47 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HBB | P68871 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31045506 | 0.95 | DPYD (0.46) | DPYDATAD2GPR84LMNAMAPT | |
| SCHEMBL16585678 | 0.94 | GPR84 (0.46) | DPYDATAD2GPR84MAPTALDH1A1 | |
| SCHEMBL1890981 | 0.90 | DPYD (0.50) | DPYDATAD2LMNAMAPTSMN1; SMN2 | |
| SCHEMBL30504798 | 0.89 | DPYD (0.44) | DPYDATAD2GPR84LMNAMAPT | |
| SCHEMBL16586721 | 0.86 | GPR84 (0.43) | DPYDGPR84LMNAMAPTSMN1; SMN2 | |
| SCHEMBL16586691 | 0.86 | GPR84 (0.43) | DPYDGPR84LMNAMAPTSMN1; SMN2 | |
| SCHEMBL1586447 | 0.86 | DPYD (0.40) | DPYDGPR84LMNAMAPTSMN1; SMN2 | |
| SCHEMBL1586445 | 0.86 | DPYD (0.40) | DPYDGPR84LMNAMAPTSMN1; SMN2 | |
| SCHEMBL3485393 | 0.83 | DPYD (0.53) | DPYDATAD2LMNAMAPTSMN1; SMN2 | |
| SCHEMBL31045516 | 0.83 | DPYD (0.54) | DPYDATAD2LMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8440442-B2 | Method of assaying 5-FU | MYRIAD GENETICS, INC (US) | 2013-05-14 | — | — | US | claimed |
| US-7229974-B2 | G cap-stabilized oligonucleotides | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-06-12 | — | — | US | claimed |
| EP-0818460-B1 | Synthesis of Oligonucleotides on a solid support. | AVENTIS PHARMA GMBH (DE) | 2003-01-15 | — | — | EP | claimed |
| US-20020151512-A1 | G cap-stabilized oligonucleotides | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2002-10-17 | — | — | US | claimed |
| EP-0726274-B1 | G-cap stabilized oligonucleotides | AVENTIS PHARMA GMBH (DE) | 2001-10-10 | — | — | EP | claimed |
| EP-0739898-B1 | Phosphonomonoester nucleic acids, methods for their preparation and their use | AVENTIS PHARMA GMBH (DE) | 2001-09-26 | — | — | EP | claimed |
| EP-0985415-A1 | Uracil reductase inactivators | THE WELLCOME FOUNDATION LIMITED (GB) | 2000-03-15 | — | — | EP | claimed |
| US-6013639-A | MODIFYING END GROUPS; DIAGNOSIS, THERAPY CANCER, RESTENOSIS | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-01-11 | — | — | US | claimed |
| US-5936077-A | PROTECTING EXOCYCLIC AMINO GROUPS OF NUCLEOTIDE WITH A CYCLIC DIACYL GROUP; COUPLING NUCLEOTIDE TO SOLID SUPPORT; SEQUENTIALLY LINKING NUCLEOTIDES TOGETHER; DEPROTECTING WITH STRONG, NONNUCLEOPHILIC BASE IN ORGANIC SOLVENT | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-08-10 | — | — | US | claimed |
| US-5874553-A | ANTIBODIES; INHIBITOR OF GENE EXPRESSION | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-02-23 | — | — | US | claimed |
| US-5817664-A | ANTITUMOR, ANTICANCER AGENTS | GLAXO WELLCOME INC. (US) | 1998-10-06 | — | — | US | claimed |
| EP-0726904-A1 | 5-FLUOROURACIL DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-08-21 | — | — | EP | claimed |
| WO-1995012606-A1 | 5-FLUOROURACIL DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-05-11 | — | — | WO | claimed |
| EP-3792634-A2 | METHOD OF ASSAYING 5-FU | Myriad Genetics, Inc. (US) | 2021-03-17 | — | — | EP | disclosed |
| WO-2014089004-A1 | METHODS FOR TREATING 5-FLUOROURACIL PRODRUG NON-RESPONSIVE CANCER PATIENTS | ADHEREX TECHNOLOGIES, INC. (US) | 2014-06-12 | — | — | WO | disclosed |
| US-8658618-B2 | Methods for preventing or reducing neurotoxicity associated with administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs | ADHEREX TECHNOLOGIES, INC. (US) | 2014-02-25 | — | — | US | disclosed |
| EP-0681586-A1 | OLIGODEOXYNUCLEOTIDES CONTAINING 5-ALKYL-, 5-(1-ALKENYL)- AND 5-(1-ALKYNYL)PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS | MTA Kösponti Kémiai Kutato Intézet (HU) | 1995-11-15 | — | — | EP | disclosed |
| WO-1994017094-A1 | OLIGODEOXYNUCLEOTIDES CONTAINING 5-ALKYL-, 5-(1-ALKENYL)- AND 5-(1-ALKYNYL)PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS | MTA KÖSPONTI KÉMIAI KUTATÓ INTÉZET (HU) | 1994-08-04 | — | — | WO | disclosed |
| EP-0539442-A1 | ENZYME INACTIVATORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-05-05 | — | — | EP | disclosed |
| WO-1992001452-A1 | ENZYME INACTIVATORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-02-06 | — | — | WO | disclosed |