Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPYD | Q12882 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1586447 | 1.00 | DPYD (0.40) | DPYDCYP3A4KDM4EMAPTHSD17B10 | |
| SCHEMBL1050748 | 0.86 | DPYD (0.47) | DPYDCYP3A4KDM4EMAPTHSD17B10 | |
| SCHEMBL31045506 | 0.82 | DPYD (0.46) | DPYDCYP3A4MAPTLMNACYP2C9 | |
| SCHEMBL16585678 | 0.81 | GPR84 (0.46) | DPYDCYP3A4KDM4EMAPTHSD17B10 | |
| SCHEMBL1890981 | 0.77 | DPYD (0.50) | DPYDKDM4EMAPTLMNASMN1; SMN2 | |
| SCHEMBL30504798 | 0.77 | DPYD (0.44) | DPYDMAPTLMNASMN1; SMN2TSHR | |
| SCHEMBL15798473 | 0.76 | DPYD (0.62) | DPYDKDM4EMAPTLMNASMN1; SMN2 | |
| SCHEMBL65892 | 0.76 | DPYD (0.62) | DPYDKDM4EMAPTLMNASMN1; SMN2 | |
| SCHEMBL190003 | 0.76 | DPYD (0.62) | DPYDKDM4EMAPTLMNASMN1; SMN2 | |
| SCHEMBL16586721 | 0.74 | GPR84 (0.43) | DPYDCYP3A4KDM4EMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130184232-A1 | METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS | SPECTOR THOMAS (US) | 2013-07-18 | — | — | US | claimed |
| EP-2488182-A1 | TREATING NEUROTOXICITY ASSOCIATED WITH COMBINATIONS OF 5 - FU OR ITS PRODRUGS AND DPD INHIBITORS | Adherex Technologies, Inc. (CA) | 2012-08-22 | — | — | EP | claimed |
| US-20110130359-A1 | METHODS FOR PREVENTING OR REDUCING NEUROTOXICITY ASSOCIATED WITH ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS | ADHEREX TECHNOLOGIES, INC. (US) | 2011-06-02 | — | — | US | claimed |
| WO-2011047195-A1 | TREATING NEUROTOXICITY ASSOCIATED WITH COMBINATIONS OF 5 - FU OR ITS PRODRUGS AND DPD INHIBITORS | ADHEREX TECHNOLOGIES, INC. (CA) | 2011-04-21 | — | — | WO | claimed |
| WO-2009100367-A2 | COMPOSITIONS COMPRISING TOPICAL DPD INHIBITORS AND METHODS OF USING SAME IN THE TREATMENT OF HAND-FOOT SYNDROME | ADHEREX TECHNOLOGIES INC. (CA) | 2009-08-13 | — | — | WO | claimed |
| US-20090196833-A1 | COMPOSITIONS COMPRISING TOPICAL DPD INHIBITORS AND METHODS OF USING SAME IN THE TREATMENT OF HAND-FOOT SYNDROME | ADHEREX TECHNOLOGIES INC. (CA) | 2009-08-06 | — | — | US | claimed |
| US-20080255168-A1 | METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS | ADHEREX TECHNOLOGIES, INC. (CA) | 2008-10-16 | — | — | US | claimed |
| EP-1827443-A1 | METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS | Adherex Technologies, Inc. (CA) | 2007-09-05 | — | — | EP | claimed |
| WO-2006060697-A9 | METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS | ADHEREX TECHNOLOGIES INC (CA) | 2006-09-21 | — | — | WO | claimed |
| US-20060148753-A1 | Methods for administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs | ADHEREX TECHNOLOGIES, INC. (CA) | 2006-07-06 | — | — | US | claimed |
| WO-2006060697-A1 | METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS | ADHEREX TECHNOLOGIES, INC. (CA) | 2006-06-08 | — | — | WO | claimed |
| EP-2488182-B1 | Treating neurotoxicity associated with combinations of 5-FU or its prodrugs and DPD inhibitors | ELION ONCOLOGY LLC (US) | 2017-07-19 | — | — | EP | disclosed |
| WO-2014089004-A1 | METHODS FOR TREATING 5-FLUOROURACIL PRODRUG NON-RESPONSIVE CANCER PATIENTS | ADHEREX TECHNOLOGIES, INC. (US) | 2014-06-12 | — | — | WO | disclosed |
| US-8658618-B2 | Methods for preventing or reducing neurotoxicity associated with administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs | ADHEREX TECHNOLOGIES, INC. (US) | 2014-02-25 | — | — | US | disclosed |
| US-20130184232-A1 | METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS | SPECTOR THOMAS (US) | 2013-07-18 | — | — | US | disclosed |
| US-20080255168-A1 | METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS | ADHEREX TECHNOLOGIES, INC. (CA) | 2008-10-16 | — | — | US | disclosed |
| EP-1827443-A1 | METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS | Adherex Technologies, Inc. (CA) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006060697-A9 | METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS | ADHEREX TECHNOLOGIES INC (CA) | 2006-09-21 | — | — | WO | disclosed |
| US-20060148753-A1 | Methods for administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs | ADHEREX TECHNOLOGIES, INC. (CA) | 2006-07-06 | — | — | US | disclosed |
| WO-2006060697-A1 | METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS | ADHEREX TECHNOLOGIES, INC. (CA) | 2006-06-08 | — | — | WO | disclosed |