SCHEMBL105134

SCHEMBL105134

O=C(Oc1ccccc1)c1ccc(Br)cc1

nearest known ligand 0.59

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PARP10 Q53GL7 1/20 0.59
PRSS1 P07477 1/20 0.57
ACR P10323 1/20 0.57
TMPRSS15 P98073 1/20 0.57
NSD2 O96028 1/20 0.55
NPC1 O15118 2/20 0.54
RAB9A P51151 2/20 0.54
HPGD P15428 1/20 0.54
MAPT P10636 6/20 0.54
SMN1; SMN2 Q16637 3/20 0.54
KMT2A Q03164 6/20 0.53
MEN1 O00255 3/20 0.53
ALDH1A1 P00352 4/20 0.51
TDP1 Q9NUW8 2/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
PKM P14618 1/20 0.51
TSHR P16473 1/20 0.50
ESR1 P03372 1/20 0.50
ESR2 Q92731 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6196601 0.94 PARP10 (0.54) PARP10PRSS1ACRTMPRSS15NSD2
SCHEMBL6060174 0.92 PARP10 (0.65) PARP10NSD2NPC1RAB9AHPGD
SCHEMBL70034 0.89 PARP10 (0.70) PARP10PRSS1ACRTMPRSS15NSD2
SCHEMBL28343302 0.89 PARP10 (0.62) PARP10PRSS1ACRTMPRSS15NPC1
SCHEMBL8205435 0.85 PARP10 (0.78) PARP10PRSS1ACRTMPRSS15NSD2
SCHEMBL31888 0.85 PARP10 (0.70) PARP10PRSS1ACRTMPRSS15NSD2
SCHEMBL1870544 0.85 PARP10 (0.70) PARP10PRSS1ACRTMPRSS15NSD2
Terephthalic Acid SCHEMBL28437942 0.83 PARP10 (0.63) PARP10PRSS1ACRTMPRSS15NSD2
SCHEMBL817796 0.83 PARP10 (0.63) PARP10PRSS1ACRTMPRSS15NSD2
SCHEMBL68278 0.83 PARP10 (0.63) PARP10PRSS1ACRTMPRSS15NSD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025072151-A1 SELECTIVE PARTIAL REDUCTION OF ESTERS USING GROUP IV TRANSITION METAL CATALYSTS AND USES THEREOF BAYLOR UNIVERSITY (US) 2025-04-03 WO disclosed
US-20250100984-A1 SELECTIVE PARTIAL REDUCTION OF ESTERS USING GROUP IV TRANSITION METAL CATALYSTS AND USES THEREOF BAYLOR UNIVERSITY (US) 2025-03-27 US disclosed
CN-112110817-B Method for preparing diaryl ester compound by high-efficiency catalysis of palladium pyridine 陕西师范大学 2022-07-26 CN disclosed
CN-112110817-A Method for preparing diaryl ester compound by high-efficiency catalysis of palladium pyridine 陕西师范大学 2020-12-22 CN disclosed
US-8853207-B2 Heterocyclic pyrazole compounds, method for preparing the same and use thereof DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) 2014-10-07 US disclosed
US-20130274255-A1 HETEROCYCLIC PYRAZOLE COMPOUNDS, METHOD FOR PREPARING THE SAME AND USE THEREOF DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) 2013-10-17 US disclosed
US-8410303-B2 Direct conversion of phenols into amides and esters of benzoic acid The Florida State University Research Foundation, Inc. (US) 2013-04-02 US disclosed
US-8410303-B2 Direct conversion of phenols into amides and esters of benzoic acid The Florida State University Research Foundation, Inc. (US) 2013-04-02 US disclosed
EP-2460805-A1 FUSED IMIDAZOLE DERIVATIVE HAVING TTK INHIBITORY ACTION Oncotherapy Science, Inc. (JP) 2012-06-06 EP disclosed
US-20120059162-A1 FUSED IMIDAZOLE DERIVATIVE HAVING TTK INHIBITORY ACTION ONCOTHERAPY SCIENCE, INC. (JP) 2012-03-08 US disclosed
EP-1138712-A2 Polyarylene copolymers and proton-conductive membrane JSR Corporation (JP) 2001-10-04 EP disclosed
US-4411903-A 4-[(Monosubstituted-alkyl)amino]benzoic acids and analogs as hypolipidemic and antiatherosclerotic agents AMERICAN CYANAMID COMPANY (US) 1983-10-25 US disclosed
US-4311846-A 4-[(Monosubstituted-alkyl) amino]benzoic acids and analogs as hypolipidemic and antiatherosclerotic agents AMERICAN CYANAMID COMPANY (US) 1982-01-19 US disclosed
US-4281018-A HYPOLIPIDEMIC AND ANTIATHEROSCLEROTIC AGENTS AMERICAN CYANAMID COMPANY (US) 1981-07-28 US disclosed
US-4272546-A ANTILIPEMIC, ANTIATHEROSCLEROTIC AMERICAN CYANAMID COMPANY (US) 1981-06-09 US disclosed
US-4254138-A ANTILIPEMIC AGENTS AND ANTIATHEROSCLEROTIC AGENTS AMERICAN CYANAMID COMPANY (US) 1981-03-03 US disclosed
US-4245097-A 4-[(Monosubstituted-alkyl) amino] benzoic acids and analogs as hypolipidemic and antiatherosclerotic agents AMERICAN CYANAMID COMPANY (US) 1981-01-13 US disclosed
US-4230628-A HYPOLIPIDEMIC AGENTS, ANTIATHEROSCLEROSIS AMERICAN CYANAMID COMPANY (US) 1980-10-28 US disclosed
US-4196208-A ANTILIPEMIC AGENTS AMERICAN CYANAMID COMPANY (US) 1980-04-01 US disclosed
EP-0003663-A2 Amino-substituted phenyl and heteroaryl compounds, process for their preparation and pharmaceutical compositions containing them AMERICAN CYANAMID COMPANY (US) 1979-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120059162-A1 FUSED IMIDAZOLE DERIVATIVE HAVING TTK INHIBITORY ACTION NR0B1, GRK7, NR5A2 PARP10 2662/4885PRSS1 4598/4885ACR 4846/4885
US-20250100984-A1 SELECTIVE PARTIAL REDUCTION OF ESTERS USING GROUP IV TRANSITION METAL CATALYSTS AND USES THEREOF ADH1A, ADH5, ADH1C PARP10 332/4885PRSS1 1679/4885ACR 3073/4885
US-20130274255-A1 HETEROCYCLIC PYRAZOLE COMPOUNDS, METHOD FOR PREPARING THE SAME AND USE THEREOF RET, FLT3, FGFR1 PARP10 3251/4885PRSS1 1067/4885ACR 3986/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.