SCHEMBL10519119

SCHEMBL10519119

FC(F)(F)c1ccc(Oc2cccc(NCl)c2)c(Cl)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
STK39 Q9UEW8 1/20 0.48
FFAR1 O14842 3/20 0.46
EGFR P00533 4/20 0.46
ERBB2 P04626 4/20 0.46
ERBB3 P21860 2/20 0.46
ERBB4 Q15303 2/20 0.46
NPSR1 Q6W5P4 2/20 0.46
MAPT P10636 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
MEN1 O00255 1/20 0.46
TTR P02766 1/20 0.46
PPOX P50336 1/20 0.46
KMT2A Q03164 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
HTR2A P28223 2/20 0.44
SLC6A4 P31645 2/20 0.44
KCNH2 Q12809 2/20 0.44
MRGPRX4 Q96LA9 3/20 0.43
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11238504 0.88 MRGPRX4 (0.48) STK39FFAR1EGFRERBB2ERBB3
SCHEMBL10538095 0.87 NPSR1 (0.57) STK39FFAR1EGFRERBB2ERBB3
SCHEMBL11121304 0.83 STK39 (0.50) STK39FFAR1EGFRERBB2ERBB3
SCHEMBL11648951 0.82 FFAR1 (0.50) STK39FFAR1EGFRERBB2ERBB3
SCHEMBL9132379 0.81 FFAR1 (0.49) STK39FFAR1EGFRERBB2ERBB3
SCHEMBL9003844 0.81 FFAR1 (0.60) FFAR1NPSR1MAPTL3MBTL1MEN1
SCHEMBL11099693 0.80 STK39 (0.54) STK39EGFRERBB2NPSR1MEN1
SCHEMBL8813323 0.80 MRGPRX4 (0.61) STK39FFAR1EGFRERBB2ERBB3
SCHEMBL7597428 0.80 L3MBTL1 (0.51) STK39FFAR1EGFRERBB2ERBB3
SCHEMBL14018271 0.80 FFAR1 (0.48) STK39FFAR1EGFRERBB2ERBB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0313908-A2 Halogen-substituted phenoxyphenylpropionic acid derivatives BAYER AG (DE) 1989-05-03 EP disclosed