Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.41 |
| ▸ | NOS1 | P29475 | 2/20 | 0.40 |
| ▸ | LSS | P48449 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10521863 | 0.91 | LSS (0.50) | TSHRROCK1ROCK2NOS1LSS | |
| SCHEMBL10518550 | 0.86 | TSHR (0.56) | TSHRRECQLCYP3A4CYP2C9KDM4E | |
| SCHEMBL10521092 | 0.86 | ALDH1A1 (0.37) | TSHRRECQLROCK1LSSCYP3A4 | |
| SCHEMBL10519080 | 0.83 | HRH2 (0.47) | ROCK1PRKACASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL10518366 | 0.80 | MAPT (0.53) | TSHRROCK1ROCK2NOS1LSS | |
| SCHEMBL10520147 | 0.79 | LSS (0.41) | TSHRRECQLROCK1ROCK2LSS | |
| SCHEMBL10518291 | 0.77 | ALDH1A1 (0.45) | ROCK1ROCK2SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL10520446 | 0.77 | ALDH1A1 (0.42) | TSHRSMN1; SMN2KDM4EMEN1ALDH1A1 | |
| SCHEMBL10518226 | 0.76 | KMT2A (0.54) | TSHRCYP2C9HDAC1HDAC8SMN1; SMN2 | |
| SCHEMBL10521093 | 0.76 | LSS (0.47) | ROCK1ROCK2NOS1LSSNOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0183191-B1 | THIENYLTHIAZOLE COMPOUNDS | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1989-05-10 | — | — | EP | disclosed |
| US-4720493-A | Thienylthiazole compounds | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1988-01-19 | — | — | US | disclosed |
| EP-0183191-A1 | Thienylthiazole compounds | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1986-06-04 | — | — | EP | disclosed |