Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.44 |
| ▸ | NOS1 | P29475 | 2/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10519858 | 0.91 | TSHR (0.43) | LSSROCK1ROCK2NOS1NOS2 | |
| SCHEMBL10518366 | 0.88 | MAPT (0.53) | LSSROCK1ROCK2NOS1NOS2 | |
| SCHEMBL10518226 | 0.85 | KMT2A (0.54) | HPGDKMT2ANPC1SMN1; SMN2GLA | |
| SCHEMBL10520147 | 0.85 | LSS (0.41) | LSSROCK1ROCK2HPGDKMT2A | |
| SCHEMBL10521093 | 0.85 | LSS (0.47) | LSSROCK1ROCK2NOS1NOS2 | |
| SCHEMBL10521013 | 0.82 | HRH2 (0.48) | ROCK1KMT2ASMN1; SMN2PRKACALMNA | |
| SCHEMBL10868918 | 0.80 | NOS1 (0.41) | LSSROCK1ROCK2NOS1NOS2 | |
| SCHEMBL10521092 | 0.79 | ALDH1A1 (0.37) | LSSROCK1HPGDKMT2ARAB9A | |
| SCHEMBL10621504 | 0.76 | ALDH1A1 (0.46) | HPGDKMT2ARAB9ANPC1MAPT | |
| SCHEMBL10518550 | 0.76 | TSHR (0.56) | HPGDKMT2ACYP3A4LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0183191-B1 | THIENYLTHIAZOLE COMPOUNDS | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1989-05-10 | — | — | EP | disclosed |
| US-4720493-A | Thienylthiazole compounds | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1988-01-19 | — | — | US | disclosed |
| EP-0183191-A1 | Thienylthiazole compounds | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1986-06-04 | — | — | EP | disclosed |