Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.39 |
| ▸ | APEX1 | P27695 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.37 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.32 |
| ▸ | APAF1 | O14727 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16342162 | 0.98 | MEN1 (0.41) | APEX1NPSR1MEN1KMT2AACHE | |
| SCHEMBL17937650 | 0.78 | MEN1 (0.41) | APEX1NPSR1MEN1KMT2AACHE | |
| Hydrochloric Acid SCHEMBL31003437 | 0.78 | LMNA (0.55) | APEX1NPSR1MEN1KMT2AACHE | |
| Hydrochloric Acid SCHEMBL10586515 | 0.78 | LMNA (0.55) | APEX1NPSR1MEN1KMT2AACHE | |
| Hydrochloric Acid SCHEMBL120655 | 0.78 | LMNA (0.55) | APEX1NPSR1MEN1KMT2AACHE | |
| SCHEMBL15112915 | 0.77 | LMNA (0.46) | KMT2ALMNADNM1BBOX1HSP90AA1 | |
| Hydrochloric Acid SCHEMBL667334 | 0.76 | LMNA (0.53) | APEX1NPSR1MEN1KMT2AACHE | |
| SCHEMBL704740 | 0.76 | — | — | |
| SCHEMBL646421 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL9418686 | 0.76 | LMNA (0.53) | KMT2ALMNADNM1HSP90AA1RAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1989004164-A1 | HAIR CONDITIONING COMPOSITION | DOW CORNING LIMITED (GB) | 1989-05-18 | — | — | WO | disclosed |