Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 4/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6758056 | 0.80 | TAAR1 (0.51) | LOXL2 | |
| SCHEMBL7738327 | 0.78 | AKR1B1 (0.38) | NLRP3IDO1LOXL2GAASMN1; SMN2 | |
| SCHEMBL8519473 | 0.76 | TBXAS1 (0.50) | GAASMN1; SMN2KDM4EHTT | |
| SCHEMBL7731325 | 0.75 | TBXAS1 (0.35) | IDO1LOXL2SMN1; SMN2MIFGSK3B | |
| SCHEMBL27736989 | 0.74 | MTNR1A (0.54) | NLRP3IDO1MTNR1AMTNR1BLOXL2 | |
| SCHEMBL3451201 | 0.73 | LOXL2 (0.58) | NLRP3IDO1MTNR1AMTNR1BLOXL2 | |
| SCHEMBL28935948 | 0.73 | LOXL2 (0.50) | NLRP3IDO1MTNR1AMTNR1BLOXL2 | |
| SCHEMBL28762418 | 0.73 | NLRP3 (0.53) | NLRP3IDO1MTNR1AMTNR1BLOXL2 | |
| SCHEMBL29365671 | 0.72 | LOXL2 (0.56) | NLRP3IDO1MTNR1AMTNR1BLOXL2 | |
| SCHEMBL49270 | 0.72 | LOXL2 (0.56) | NLRP3IDO1MTNR1AMTNR1BLOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4808581-A | ANXIOLYTIC, ANTIEMETIC, TREATMENT OF PSYCHOLOGICAL DISORDERS | GLAXO GROUP LIMITED (GB) | 1989-02-28 | — | — | US | disclosed |