Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 7/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.36 |
| ▸ | CD74 | P04233 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10548634 | 0.82 | CCR2 (0.56) | CCR2TSHRMAPK1 | |
| SCHEMBL10543693 | 0.82 | CCR2 (0.56) | CCR2CYP11B1CYP11B2POLB | |
| SCHEMBL10543086 | 0.80 | CNR2 (0.46) | CCR2TSHRSMN1; SMN2MAPK1 | |
| SCHEMBL10546918 | 0.76 | CCR2 (0.37) | CCR2MAPK1 | |
| SCHEMBL15654050 | 0.76 | PKM (0.49) | CCR2CYP11B1CYP11B2POLBSMN1; SMN2 | |
| SCHEMBL7165398 | 0.70 | POLB (0.63) | POLBHTTMAPK1 | |
| SCHEMBL11340082 | 0.70 | PTGDR2 (0.41) | — | |
| SCHEMBL1752323 | 0.70 | GPR35 (0.40) | POLBTSHRGPR35MAPK1 | |
| SCHEMBL7247406 | 0.69 | XDH (0.46) | CYP11B1CYP11B2POLBHTTSMN1; SMN2 | |
| SCHEMBL4418297 | 0.67 | HPGDS (0.51) | CCR2POLBTSHRSMN1; SMN2GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4859779-A | ENZYME INHIBITORS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-08-22 | — | — | US | disclosed |
| US-4837353-A | 2-/N-PHENYLALKYL-N-FORMYL/AMINO-3-HYDROXY-2-PROPENOIC ACID DERIVATIVES | SMITHKLINE BECKMAN CORPORATION (US) | 1989-06-06 | — | — | US | disclosed |
| EP-0284375-A1 | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1988-09-28 | — | — | EP | disclosed |
| US-4762850-A | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BECKMAN CORPORATION (US) | 1988-08-09 | — | — | US | disclosed |