SCHEMBL1056576

SCHEMBL1056576

COc1cc2nc(-c3ccccc3Cl)nc(Nc3ccncc3)c2cc1OC

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 6/20 0.67
MEN1 O00255 6/20 0.67
KMT2A Q03164 6/20 0.67
CYP1A2 P05177 5/20 0.67
CYP3A4 P08684 5/20 0.67
ALDH1A1 P00352 4/20 0.67
CYP2D6 P10635 4/20 0.67
CYP2C19 P33261 4/20 0.67
CLK4 Q9HAZ1 3/20 0.67
USP2 O75604 2/20 0.67
CYP2C9 P11712 2/20 0.67
HSD17B10 Q99714 3/20 0.64
ALOX15 P16050 2/20 0.64
MAPK1 P28482 2/20 0.64
TP53 P04637 5/20 0.53
MAPT P10636 5/20 0.53
ABCG2 Q9UNQ0 3/20 0.52
KDM4E B2RXH2 2/20 0.52
HPGD P15428 2/20 0.52
CASP1 P29466 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4092472 0.87 LMNA (0.67) LMNAMEN1KMT2ACYP1A2CYP3A4
SCHEMBL413342 0.81 CYP1A2 (1.00) LMNAMEN1KMT2ACYP1A2CYP3A4
SCHEMBL14262815 0.81 CYP1A2 (0.65) LMNAMEN1KMT2ACYP1A2CYP3A4
SCHEMBL17372601 0.80 ACP1 (0.51) LMNAMEN1KMT2ACYP1A2CYP3A4
SCHEMBL414375 0.79 LMNA (0.59) LMNAMEN1KMT2ACYP1A2CYP3A4
SCHEMBL16404462 0.76 ABCG2 (0.70) MEN1KMT2AABCG2ABCB1EGFR
SCHEMBL16404474 0.76 ABCG2 (0.74) MEN1KMT2ATP53MAPTABCG2
SCHEMBL15280232 0.74 EGFR (0.76) ABCG2EGFRKDRSLC2A1
SCHEMBL4847453 0.73 ALDH1A1 (0.71) LMNAMEN1KMT2ACYP1A2CYP3A4
SCHEMBL14474025 0.72 ABCG2 (0.63) LMNAMEN1KMT2ACYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110008289-A1 HYPERGLYCOSYLATED POLYPEPTIDE VARIANTS AND METHODS OF USE ALIOS BIOPHARMA, INC. (US) 2011-01-13 US disclosed
US-20100099851-A1 SYNTHETIC HYPERGLYCOSYLATED, PROTEASE-RESISTANT POLYPEPTIDE VARIANTS, ORAL FORMULATIONS AND METHODS OF USING THE SAME ALIOS BIOPHARMA, INC. (US) 2010-04-22 US disclosed
US-7597884-B2 Hyperglycosylated polypeptide variants and methods of use ALIOS BIOPHARMA, INC. (US) 2009-10-06 US disclosed
EP-2093235-A1 Hyperglycosylated variants of interferon alfacon-1 Alios Biopharma Inc. (US) 2009-08-26 EP disclosed
EP-1789074-A4 SYNTHETIC HYPERGLYCOSYLATED, PROTEASE-RESISTANT POLYPEPTIDE VARIANTS, ORAL FORMULATIONS AND METHODS OF USING THE SAME ALIOS BIOPHARMA INC (US) 2009-08-12 EP disclosed
EP-1987060-A2 SYNTHETIC HYPERGLYCOSYLATED, AND HYPERGLYCOSYLATED PROTEASE-RESISTANT POLYPEPTIDE VARIANTS, ORAL FORMULATIONS AND METHODS OF USING THE SAME Alios Biopharma Inc. (US) 2008-11-05 EP disclosed
EP-1575506-A4 METHODS FOR IMPROVEMENT OF LUNG FUNCTION USING TGF-BETA INHIBITORS SCIOS INC (US) 2008-04-23 EP disclosed
US-7345045-B2 Pyrido-pyrimidine compounds as medicaments SCIOS, INC. (US) 2008-03-18 US disclosed
EP-1572208-A4 METHOD FOR COUNTERACTING A PATHOLOGIC CHANGE IN THE BETA-ADRENERGIC PATHWAY SCIOS INC (US) 2007-08-29 EP disclosed
WO-2007092537-A2 SYNTHETIC HYPERGLYCOSYLATED, AND HYPERGLYCOSYLATED PROTEASE-RESISTANT POLYPEPTIDE VARIANTS, ORAL FORMULATIONS AND METHODS OF USING THE SAME ALIOS BIOPHARMA, INC. (US) 2007-08-16 WO disclosed
WO-2004010929-A2 METHODS FOR IMPROVEMENT OF LUNG FUNCTION USING TGF-β INHIBITORS SCIOS, INC. (US) 2004-02-05 WO disclosed
WO-2003097615-A1 TREATMENT OF FIBROPROLIFERATIVE DISORDERS USING TGF-β INHIBITORS SCIOS, INC. (US) 2003-11-27 WO disclosed
US-20030069248-A1 Quinazoline derivatives as medicaments CHAKRAVARTY SARVAJIT (US) 2003-04-10 US disclosed
US-6476031-B1 Quinazoline derivatives as medicaments SCIOS, INC. 2002-11-05 US disclosed
US-20020161010-A1 Quinazoline derivatives as medicaments CHAKRAVARTY SARVAJIT (US) 2002-10-31 US disclosed
CN-1333757-A Quinazoline derivatives as medicaments SCIOS INC (US) 2002-01-30 CN disclosed
US-6277989-B1 USEFUL IN TREATING CONDITIONS THAT ARE CHARACTERIZED BY ENHANCED P38 KINASE ACTIVITY AND/OR TRANSFORMING GROWTH FACTOR BETA (TGF-.BETA.) ACTIVITY SUCH AS INFLAMMATION, PROLIFERATIVE DISEASES, AND CERTAIN CARDIOVASCULAR DISORDERS SCIOS, INC. 2001-08-21 US disclosed
EP-1107959-A2 QUINAZOLINE DERIVATIVES AS MEDICAMENTS SCIOS INC. (US) 2001-06-20 EP disclosed
US-6184226-B1 ANTIINFLAMMATORY AGENTS FOR TREATMENT OF CARDIOVASCULAR SYSTEM DISORDERS/RESPIRATORY SYSTEM DISORDERS, ANTIISCHEMIC AGENTS SCIOS INC. 2001-02-06 US disclosed
WO-2000012497-A2 QUINAZOLINE DERIVATIVES AS MEDICAMENTS SCIOS INC. (US) 2000-03-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020161010-A1 Quinazoline derivatives as medicaments SMAD3, SMAD2, TGFBR1 LMNA 2827/4885MEN1 1621/4885KMT2A 2523/4885
US-20100099851-A1 SYNTHETIC HYPERGLYCOSYLATED, PROTEASE-RESISTANT POLYPEPTIDE VARIANTS, ORAL FORMULATIONS AND METHODS OF USING THE SAME IFNAR1, IDE, CTSC LMNA 3227/4885MEN1 3779/4885KMT2A 4519/4885
US-20110008289-A1 HYPERGLYCOSYLATED POLYPEPTIDE VARIANTS AND METHODS OF USE IFNAR1, EPOR, HBB LMNA 2682/4885MEN1 3843/4885KMT2A 4668/4885
US-20030069248-A1 Quinazoline derivatives as medicaments SMAD3, SMAD2, TGFBR1 LMNA 2827/4885MEN1 1621/4885KMT2A 2523/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.