SCHEMBL10568558

SCHEMBL10568558

Cc1cc(C)nc(NC(=O)NS(=O)(=O)c2cc3ccccc3[nH]2)n1

nearest known ligand 0.55

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.45
CNR1 P21554 7/20 0.45
LMNA P02545 1/20 0.44
CA2 P00918 1/20 0.43
ALOX15 P16050 1/20 0.43
ALDH1A1 P00352 2/20 0.43
TSHR P16473 2/20 0.43
CCKAR P32238 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10874920 0.82 GAA (0.49) GAALMNAALOX15ALDH1A1TSHR
SCHEMBL10565694 0.79 CNR1 (0.46) GAACNR1LMNAALOX15ALDH1A1
SCHEMBL10762436 0.78 TSHR (0.63) GAALMNAALOX15ALDH1A1TSHR
SCHEMBL6923052 0.77 CA2 (0.54) CNR1CA2CCKAR
SCHEMBL9569772 0.77 CA2 (0.44) CNR1LMNACA2ALDH1A1CCKAR
SCHEMBL10362397 0.76 NLRP3 (0.55) GAALMNAALOX15ALDH1A1TSHR
SCHEMBL10567613 0.76 MEN1 (0.45) GAALMNAALOX15ALDH1A1TSHR
SCHEMBL5813841 0.76 NTRK1 (0.60) GAACNR1ALDH1A1
SCHEMBL11326481 0.76 FBP1 (0.54) GAALMNACA2ALOX15ALDH1A1
SCHEMBL11326475 0.76 FBP1 (0.54) GAALMNACA2ALOX15ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4836846-A PRE/POST EMERGENCE; WEEDS, GRASSES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1989-06-06 US disclosed
US-4764610-A Herbicidal indole sulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1988-08-16 US disclosed
EP-0070698-B1 HERBICIDAL INDOLE SULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1985-11-13 EP disclosed
EP-0070698-A1 Herbicidal indole sulfonamides E.I. DU PONT DE NEMOURS AND COMPANY (US) 1983-01-26 EP disclosed