Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 7/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | CBFB | Q13951 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | SCD | O00767 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10578360 | 0.92 | AMY1A (0.34) | AMY1ACARM1 | |
| SCHEMBL10578009 | 0.87 | THRB (0.36) | AMY1ANPBWR1METAP2SCDTHRB | |
| SCHEMBL10580112 | 0.83 | PDE5A (0.47) | AMY1ASCDHDAC6TP53 | |
| SCHEMBL10576002 | 0.82 | HDAC6 (0.36) | AMY1ATRPV1HRH4METAP2SCD | |
| SCHEMBL10574102 | 0.82 | AMY1A (0.50) | AMY1ANPBWR1HRH4 | |
| SCHEMBL10572988 | 0.82 | NPBWR1 (0.34) | AMY1ANPBWR1TRPV1CBFBMETAP2 | |
| SCHEMBL10576214 | 0.81 | AMY1A (0.41) | AMY1AHDAC6TP53 | |
| SCHEMBL10574279 | 0.81 | SLC2A1 (0.55) | NPBWR1TRPV1TP53 | |
| SCHEMBL10579371 | 0.80 | CDK4 (0.44) | AMY1ANPBWR1CBFBSCD | |
| SCHEMBL10579971 | 0.80 | NPC1 (0.49) | NPBWR1TRPV1SCDHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882342-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-11-21 | — | — | US | disclosed |
| EP-0266558-A2 | 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1988-05-11 | — | — | EP | disclosed |