Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.47 |
| ▸ | AMY1A | P0DUB6 | 8/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | PLAT | P00750 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10580104 | 0.92 | PDE5A (0.45) | PDE5AAMY1AHDAC6AURKASLC2A1 | |
| SCHEMBL10574102 | 0.87 | AMY1A (0.50) | PDE5AAMY1A | |
| SCHEMBL10576214 | 0.85 | AMY1A (0.41) | AMY1AHDAC6TP53POLBMAPT | |
| SCHEMBL10579371 | 0.85 | CDK4 (0.44) | AMY1ASCD | |
| SCHEMBL10576003 | 0.85 | NR1I2 (0.42) | AMY1ASCD | |
| SCHEMBL10575621 | 0.84 | AMY1A (0.36) | PDE5AAMY1AHDAC6TP53POLB | |
| SCHEMBL10576087 | 0.84 | ALOX5 (0.56) | AMY1AHDAC6 | |
| SCHEMBL10578367 | 0.83 | AMY1A (0.36) | AMY1AHDAC6SCDTP53 | |
| SCHEMBL10577231 | 0.83 | AMY1A (0.55) | AMY1AHDAC6 | |
| SCHEMBL10578455 | 0.83 | NPBWR1 (0.56) | HDAC6SCDTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882342-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-11-21 | — | — | US | disclosed |
| EP-0266558-A2 | 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1988-05-11 | — | — | EP | disclosed |