Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 8/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | SMPD3 | Q9NY59 | 5/20 | 0.41 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10577199 | 0.92 | AMY1A (0.47) | AMY1ASMPD3NOX1 | |
| SCHEMBL10576087 | 0.89 | ALOX5 (0.56) | AMY1AALOX5EPHX2HDAC6TRPV1 | |
| SCHEMBL10576865 | 0.86 | HDAC6 (0.43) | HDAC6TRPV1DGAT1KCNH2 | |
| SCHEMBL10574279 | 0.85 | SLC2A1 (0.55) | TRPV1 | |
| SCHEMBL10577338 | 0.84 | DGAT1 (0.57) | HDAC6TRPV1DGAT1KCNH2 | |
| SCHEMBL10580112 | 0.83 | PDE5A (0.47) | AMY1AHDAC6 | |
| SCHEMBL10574922 | 0.83 | HDAC6 (0.43) | HDAC6TRPV1DGAT1KCNH2 | |
| SCHEMBL10578455 | 0.82 | NPBWR1 (0.56) | HDAC6TRPV1DGAT1KCNH2 | |
| SCHEMBL10574094 | 0.81 | DGAT1 (0.44) | HDAC6TRPV1DGAT1KCNH2 | |
| SCHEMBL10574710 | 0.81 | NPC1 (0.51) | HDAC6TRPV1DGAT1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882342-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-11-21 | — | — | US | disclosed |
| EP-0266558-A2 | 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1988-05-11 | — | — | EP | disclosed |