Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | GSK3B | P49841 | 3/20 | 0.48 |
| ▸ | GSK3A | P49840 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
| ▸ | CCNH | P51946 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1058014 | 1.00 | KDM4E (0.49) | KDM4EALDH1A1GSK3BGSK3ARAB9A | |
| SCHEMBL1059295 | 0.92 | GSK3B (0.49) | KDM4EALDH1A1GSK3BGSK3ARAB9A | |
| SCHEMBL1059298 | 0.92 | GSK3B (0.49) | KDM4EALDH1A1GSK3BGSK3ARAB9A | |
| SCHEMBL1057335 | 0.89 | NR3C1 (0.46) | KDM4EALDH1A1GSK3BGSK3ANR3C1 | |
| SCHEMBL1057333 | 0.89 | NR3C1 (0.46) | KDM4EALDH1A1GSK3BGSK3ANR3C1 | |
| SCHEMBL1058558 | 0.88 | GSK3B (0.55) | KDM4EALDH1A1GSK3BRAB9ACCNA2 | |
| SCHEMBL1058560 | 0.88 | GSK3B (0.55) | KDM4EALDH1A1GSK3BRAB9ACCNA2 | |
| SCHEMBL1056357 | 0.85 | MAPT (0.49) | KDM4EALDH1A1GSK3BRAB9AMAPK1 | |
| SCHEMBL1056358 | 0.85 | MAPT (0.49) | KDM4EALDH1A1GSK3BRAB9AMAPK1 | |
| SCHEMBL1058207 | 0.81 | NPC1 (0.52) | KDM4EALDH1A1GSK3BRAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100204251-A1 | MOLECULAR TARGET OF NEUROTOXICITY | EXONHIT THERAPEUTICS SA (FR) | 2010-08-12 | — | — | US | claimed |
| EP-1982704-B1 | New molecular target of neurotoxicity | EXONHIT THERAPEUTICS SA (FR) | 2010-08-04 | — | — | EP | claimed |
| US-20060142326-A1 | Use of pyrazolopyridines for the treatment of cognitive deficits | DIAXONHIT (FR) | 2006-06-29 | — | — | US | claimed |
| US-20050043319-A1 | Detecting neuronal stress via monitoring in vitro expression of phosphodiesterases; diagnosis, prevention and treatment of amyotrophic lateral sclerosis and other neurodegenerative diseases; drug screening | EXONHIT THERAPEUTICS SA (FR) | 2005-02-24 | — | — | US | claimed |
| US-20040219552-A1 | Novel molecular target for neurotoxicity | EXONHIT THERAPEUTICS SA (FR) | 2004-11-04 | — | — | US | claimed |
| US-20120202846-A1 | MOLECULAR TARGET OF NEUROTOXICITY | EXONHIT THERAPEUTICS SA (FR) | 2012-08-09 | — | — | US | disclosed |
| US-7872015-B2 | Methods involving PDE4, compositions, and the screening thereof, for the treatment of degenerative ocular pathologies | EXONHIT THERAPEUTICS SA (FR) | 2011-01-18 | — | — | US | disclosed |
| US-20100204251-A1 | MOLECULAR TARGET OF NEUROTOXICITY | EXONHIT THERAPEUTICS SA (FR) | 2010-08-12 | — | — | US | disclosed |
| EP-1982704-B1 | New molecular target of neurotoxicity | EXONHIT THERAPEUTICS SA (FR) | 2010-08-04 | — | — | EP | disclosed |
| US-20090317842-A1 | Methods and Tools for The Therapy of Neurodegenerative Pathologies | EXONHIT THERAPEUTICS SA (FR) | 2009-12-24 | — | — | US | disclosed |
| EP-1417349-B1 | NOVEL MOLECULAR TARGET FOR NEUROTOXICITY | EXONHIT THERAPEUTICS SA (FR) | 2008-11-19 | — | — | EP | disclosed |
| EP-1982704-A2 | New molecular target of neurotoxicity | Exonhit Therapeutics SA (FR) | 2008-10-22 | — | — | EP | disclosed |
| US-20060241062-A1 | Method involving pde4, compositions, and the screening thereof, for the treatment of degenerative ocular pathologies | EXONHIT THERAPEUTICS SA (FR) | 2006-10-26 | — | — | US | disclosed |
| US-20060142326-A1 | Use of pyrazolopyridines for the treatment of cognitive deficits | DIAXONHIT (FR) | 2006-06-29 | — | — | US | disclosed |
| US-20050043319-A1 | Detecting neuronal stress via monitoring in vitro expression of phosphodiesterases; diagnosis, prevention and treatment of amyotrophic lateral sclerosis and other neurodegenerative diseases; drug screening | EXONHIT THERAPEUTICS SA (FR) | 2005-02-24 | — | — | US | disclosed |
| US-20040219552-A1 | Novel molecular target for neurotoxicity | EXONHIT THERAPEUTICS SA (FR) | 2004-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043319-A1 | Detecting neuronal stress via monitoring in vitro expression of phosphodiesterases; diagnosis, prevention and treatment of amyotrophic lateral sclerosis and other neurodegenerative diseases; drug screening | PDE4B, PDE4A, PDE4D | KDM4E 1723/4885ALDH1A1 1640/4885GSK3B 701/4885 |
| US-20090317842-A1 | Methods and Tools for The Therapy of Neurodegenerative Pathologies | SNCA, BACE1, BDNF | KDM4E 4634/4885ALDH1A1 1803/4885GSK3B 142/4885 |
| US-20120202846-A1 | MOLECULAR TARGET OF NEUROTOXICITY | PDE4B, TDP2, PDE4A | KDM4E 2093/4885ALDH1A1 1463/4885GSK3B 807/4885 |
| US-20060241062-A1 | Method involving pde4, compositions, and the screening thereof, for the treatment of degenerative ocular pathologies | PDE4B, PDE4A, GABRA4 | KDM4E 1353/4885ALDH1A1 645/4885GSK3B 353/4885 |
| US-20060142326-A1 | Use of pyrazolopyridines for the treatment of cognitive deficits | QDPR, ACHE, GRN | KDM4E 1945/4885ALDH1A1 2637/4885GSK3B 897/4885 |
| US-20100204251-A1 | MOLECULAR TARGET OF NEUROTOXICITY | PDE4B, TDP2, PDE4A | KDM4E 2093/4885ALDH1A1 1463/4885GSK3B 807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.