Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 4/20 | 0.52 |
| ▸ | FABP4 | P15090 | 4/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.49 |
| ▸ | FABP3 | P05413 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12584599 | 0.87 | CCR2 (0.53) | CCR2FABP4LMNAHTTSMN1; SMN2 | |
| SCHEMBL7947056 | 0.85 | CCR2 (0.55) | CCR2LMNARAB9A | |
| SCHEMBL7052102 | 0.83 | CCR2 (0.56) | CCR2 | |
| SCHEMBL9098048 | 0.83 | MAPT (0.55) | TSHRLMNASMN1; SMN2BRD4CNR1 | |
| SCHEMBL1006638 | 0.78 | GPR35 (0.44) | GPR35TSHRLMNARAB9ACNR1 | |
| SCHEMBL12951908 | 0.78 | CCR2 (0.51) | CCR2FABP4GPR35FABP3TSHR | |
| SCHEMBL10865148 | 0.77 | SMN1; SMN2 (0.49) | FABP4FABP3TSHRLMNAHTT | |
| SCHEMBL28546405 | 0.76 | PKN1 (0.48) | FABP4TSHRLMNAHTTRAB9A | |
| SCHEMBL6333151 | 0.74 | PLA2G2A (0.50) | CCR2FABP4FABP3 | |
| SCHEMBL9436526 | 0.73 | TSHR (0.44) | FABP4TSHRLMNABRD4CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4831157-A | OCRAHYDROCYCLOPENTA(B)PYRROLE-2-CARBOXYLATE | SCHERING CORPORATION (US) | 1989-05-16 | — | — | US | disclosed |
| EP-0190224-A1 | PROCESS FOR THE PREPARATION OF CIS, ENDOOCTAHYDROCYCLOPENTA [b] PYRROLE-2-CARBOXYLATE | SCHERING CORPORATION (US) | 1986-08-13 | — | — | EP | disclosed |
| US-4587258-A | HYPOTENSIVE AGENTS, CONGESTIVE HEART FAILURE | SCHERING CORPORATION (US) | 1986-05-06 | — | — | US | disclosed |
| WO-1986000896-A1 | NOVEL PROCESS FOR THE PREPARATION OF CIS, ENDOOCTAHYDROCYCLOPENTA ADb BDPYRROLE-2-CARBOXYLATE | SCHERING CORPORATION (US) | 1986-02-13 | — | — | WO | disclosed |