Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 7/20 | 0.31 |
| ▸ | ADRB1 known ✓ | P08588 | 6/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10507089 | 0.95 | L3MBTL1 (0.38) | L3MBTL1CASRHDAC6ADRB2ADRB1 | |
| Fumaric Acid SCHEMBL10593627 | 0.90 | PDE5A (0.35) | PDE5AL3MBTL1CASRHDAC6ADRB2 | |
| SCHEMBL10593153 | 0.86 | PDE5A (0.30) | PDE5AHDAC6 | |
| SCHEMBL10504052 | 0.85 | L3MBTL1 (0.37) | L3MBTL1CASRHDAC6ADRB2ADRB1 | |
| Fumaric Acid SCHEMBL10592582 | 0.84 | L3MBTL1 (0.44) | PDE5AL3MBTL1CASRADRB2ADRB1 | |
| SCHEMBL10505524 | 0.83 | ADRB2 (0.38) | ADRB2ADRB1 | |
| SCHEMBL10502904 | 0.81 | ADRB2 (0.39) | ADRB2ADRB1 | |
| SCHEMBL10503571 | 0.80 | L3MBTL1 (0.38) | L3MBTL1HDAC6ADRB2ADRB1ADRB3 | |
| SCHEMBL10503951 | 0.80 | GRK3 (0.40) | L3MBTL1CASRADRB2ADRB1ADRB3 | |
| SCHEMBL10504556 | 0.79 | L3MBTL1 (0.39) | L3MBTL1ADRB2ADRB1ADRB3GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863949-A | CARDIOVASCULAR DISORDER TREATMENT | BOEHRINGER MANNHEIM GMBH (DE) | 1989-09-05 | — | — | US | disclosed |