Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Methylmalonic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 6/20 | 0.40 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylmalonic Acid SCHEMBL21270021 | 0.96 | CA4 (0.41) | CA4CA1FAHD1CA2CYP3A4 | |
| Methylmalonic Acid SCHEMBL21269694 | 0.96 | CA4 (0.47) | CA4CA1FAHD1CA2CYP3A4 | |
| Methylmalonic Acid SCHEMBL108312 | 0.96 | — | — | |
| Methylmalonic Acid SCHEMBL29072904 | 0.96 | CA4 (0.41) | CA4CA1FAHD1CA2CYP3A4 | |
| Methylmalonic Acid SCHEMBL11586864 | 0.92 | — | — | |
| Methylmalonic Acid SCHEMBL21269785 | 0.92 | — | — | |
| Methylmalonic Acid SCHEMBL17818675 | 0.92 | CA1 (0.40) | CA4CA1CA2CYP3A4TSHR | |
| Methylmalonic Acid SCHEMBL5622821 | 0.92 | CA1 (0.40) | CA4CA1CA2CYP3A4TSHR | |
| Methylmalonic Acid SCHEMBL17818679 | 0.92 | — | — | |
| Methylmalonic Acid SCHEMBL9468796 | 0.92 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 114 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118320360-A | Easily-decomposed high-performance fire extinguishing coolant for aerosol fire extinguishing agent | 湖北及安盾消防科技有限公司 | 2024-07-12 | — | — | CN | claimed |
| US-20190256683-A1 | METAL SALTS OF MALONIC ACID AS NUCLEATING ADDITIVES FOR CRYSTALLINE THERMOPLASTICS | INDIAN OIL CORPORATION LIMITED (IN) | 2019-08-22 | — | — | US | claimed |
| EP-3527616-A1 | METAL SALTS OF MALONIC ACID AS NUCLEATING ADDITIVES FOR CRYSTALLINE THERMOPLASTICS | INDIAN OIL CORPORATION Ltd. (IN) | 2019-08-21 | — | — | EP | claimed |
| EP-1878493-B1 | Method of making a polyisocyanurate/polyurethane foam using carbocation compounds as trimerization catalysts | AIR PROD & CHEM (US) | 2013-08-21 | — | — | EP | claimed |
| US-20080161560-A1 | Process for Preparation of Calcium Salt of Rosuvastatin | DESHPANDE PANDURANG BALWANT | 2008-07-03 | — | — | US | claimed |
| EP-1869005-A1 | PROCESS FOR PREPARATION OF CALCIUM SALT OF ROSUVASTATIN | UNICHEM LABORATORIES LIMITED (IN) | 2007-12-26 | — | — | EP | claimed |
| WO-2006106526-A1 | PROCESS FOR PREPARATION OF CALCIUM SALT OF ROSUVASTATIN | UNICHEM LABORATORIES LIMITED (IN) | 2006-10-12 | — | — | WO | claimed |
| EP-0652213-B1 | Method for producing alkyl 3-phthalidylideneacetate | SUMIKA FINE CHEMICALS CO LTD (JP) | 1997-08-27 | — | — | EP | claimed |
| US-4200586-A | Inhibiting the carbon-carbon double bond isomerization of substituted or unsubstituted hydrocarbon compounds | PHILLIPS PETROLEUM COMPANY (US) | 1980-04-29 | — | — | US | claimed |
| WO-2026103793-A1 | TRICYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, AND USE THEREOF | 上海翰森生物医药科技有限公司 | 2026-05-21 | — | — | WO | disclosed |
| CN-120077048-A | Tricyclic compounds and uses thereof | 诺华股份有限公司 | 2025-05-30 | — | — | CN | disclosed |
| EP-4554569-A1 | AGENT CONTAINING MALONIC ACID OR ITS DERIVATIVES FOR RESTORING METAL HOMEOSTASIS | Oxford Antibiotic Group GmbH (AT) | 2025-05-21 | — | — | EP | disclosed |
| CN-119866217-A | Agent for restoring metal steady state containing malonic acid or derivative thereof | 牛津抗生素(制药)集团股份有限公司 | 2025-04-22 | — | — | CN | disclosed |
| CN-114616226-B | Pyridine derivatives as TMEM16A modulators for the treatment of respiratory disorders | TMEM16A有限公司 | 2025-03-04 | — | — | CN | disclosed |
| EP-0950653-A1 | Process for the preparation of potassium monoethylmalonate | CREANOVA Spezialchemie GmbH (DE) | 1999-10-20 | — | — | EP | disclosed |
| WO-1999012892-A1 | SUBSTITUTED ALKENOIC ACIDS AND THEIR DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 1999-03-18 | — | — | WO | disclosed |
| WO-1999012885-A1 | SUBSTITUTED ALKENOIC ACIDS AND THEIR DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 1999-03-18 | — | — | WO | disclosed |
| US-5849749-A | 6-(hydroxymethyl-ethyl)pyridines | BAYER AKTIENGESELLSCHAFT (DE) | 1998-12-15 | — | — | US | disclosed |
| US-4200586-A | Inhibiting the carbon-carbon double bond isomerization of substituted or unsubstituted hydrocarbon compounds | PHILLIPS PETROLEUM COMPANY (US) | 1980-04-29 | — | — | US | disclosed |
| US-4169846-A | ANTITUMOR AGENTS | INAGAKI KENJI (JP) | 1979-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190256683-A1 | METAL SALTS OF MALONIC ACID AS NUCLEATING ADDITIVES FOR CRYSTALLINE THERMOPLASTICS | NUMA1, MNS1, ME1 | CA4 1318/4885CA1 489/4885FAHD1 1433/4885 |
| US-20080161560-A1 | Process for Preparation of Calcium Salt of Rosuvastatin | CACNA1C, CACNA1E, CACNA1S | CA4 74/4885CA1 600/4885FAHD1 2259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.