Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1967927 | 0.90 | ALDH1A1 (0.53) | ALDH1A1TSHRHPGDNPC1RECQL | |
| SCHEMBL9268 | 0.81 | ALDH1A1 (0.55) | ALDH1A1TSHRHPGDNPC1RECQL | |
| Ethoxycarbonyl Group SCHEMBL27890447 | 0.81 | ALDH1A1 (0.44) | ALDH1A1TSHRHPGDHTTLMNA | |
| SCHEMBL5544885 | 0.80 | ALDH1A1 (0.54) | ALDH1A1TSHRHPGDHTTLMNA | |
| SCHEMBL20749087 | 0.80 | ALDH1A1 (0.53) | ALDH1A1TSHRHPGDNPC1RECQL | |
| SCHEMBL14719084 | 0.79 | ALDH1A1 (0.45) | ALDH1A1TSHRHPGDNPC1RECQL | |
| SCHEMBL10675147 | 0.78 | ALDH1A1 (0.55) | ALDH1A1TSHRHPGDHTTSIGMAR1 | |
| SCHEMBL3818729 | 0.78 | ALDH1A1 (0.55) | ALDH1A1TSHRHPGDNPC1RECQL | |
| SCHEMBL20590968 | 0.77 | ALDH1A1 (0.50) | ALDH1A1TSHRHPGDNPC1RECQL | |
| SCHEMBL139472 | 0.77 | ALDH1A1 (0.53) | ALDH1A1TSHRHPGDNPC1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8057997-B2 | Nucleic acid binding compounds containing pyrazolo[3,4-D]pyrimidine analogues of purin-2,6-diamine and their uses | ROCHE MOLECULAR SYSTEMS, INC. (US) | 2011-11-15 | — | — | US | disclosed |
| US-20110021365-A1 | Nucleic Acid Binding Compounds Containing Pyrazolo[3,4-D]Pyrimidine Analogues of Purin-2,6-Diamine and Their Uses | ROCHE MOLECULAR SYSTEMS, INC. | 2011-01-27 | — | — | US | disclosed |
| EP-1996947-A1 | METHOD FOR FORMING MOLECULAR SEQUENCES ON SURFACES | The Regents of the University of Michigan (US) | 2008-12-03 | — | — | EP | disclosed |
| WO-2008118167-A1 | METHOD FOR FORMING MOLECULAR SEQUENCES ON SURFACES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-10-02 | — | — | WO | disclosed |
| EP-1472372-A4 | METHODS FOR THE PREPARATION OF CHEMICALLY MISAMINOACYLATED tRNA VIA PROTECTIVE GROUPS | AMBERGEN INC (US) | 2008-08-13 | — | — | EP | disclosed |
| EP-1307469-B1 | NUCLEIC ACID BINDING COMPOUNDS CONTAINING PYRAZOLO¬3,4-D PYRIMIDINE ANALOGUES OF PURIN-2,6-DIAMINE AND THEIR USES | ROCHE DIAGNOSTICS GMBH (DE) | 2008-01-23 | — | — | EP | disclosed |
| US-20070224616-A1 | METHOD FOR FORMING MOLECULAR SEQUENCES ON SURFACES | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2007-09-27 | — | — | US | disclosed |
| US-7238795-B2 | Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses | ROCHE MOLECULAR SYSTEMS, INC. (US) | 2007-07-03 | — | — | US | disclosed |
| US-20060154256-A1 | Method for covalently attaching nucleosides and/or nucleotides on surfaces and method for determining coupling yields in the synthesis of nucleotides | CHEMOGENIX GMBH (DE) | 2006-07-13 | — | — | US | disclosed |
| EP-1472372-A1 | METHODS FOR THE PREPARATION OF CHEMICALLY MISAMINOACYLATED tRNA VIA PROTECTIVE GROUPS | Ambergen, Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| EP-1438322-A2 | METHOD FOR COVALENTLY ATTACHING NUCLEOSIDES AND/OR NUCLEOTIDES ON SURFACES AND METHOD FOR DETERMINING COUPLING YIELDS IN THE SYNTHESIS OF NUCLEOTIDES | Chemogenix GmbH (DE) | 2004-07-21 | — | — | EP | disclosed |
| US-20030198982-A1 | Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses | ROCHE MOLECULAR SYSTEMS, INC. | 2003-10-23 | — | — | US | disclosed |
| WO-2003068990-A1 | METHODS FOR THE PREPARATION OF CHEMICALLY MISAMINOACYLATED tRNA VIA PROTECTIVE GROUPS | AMBERGEN, INC. (US) | 2003-08-21 | — | — | WO | disclosed |
| EP-1307469-A1 | NUCLEIC ACID BINDING COMPOUNDS CONTAINING PYRAZOLO[3,4-D]PYRIMIDINE ANALOGUES OF PURIN-2,6-DIAMINE AND THEIR USES | BOEHRINGER MANNHEIM GMBH (DE) | 2003-05-07 | — | — | EP | disclosed |
| WO-2003035664-A2 | METHOD FOR COVALENTLY ATTACHING NUCLEOSIDES AND/OR NUCLEOTIDES ON SURFACES AND METHOD FOR DETERMINING COUPLING YIELDS IN THE SYNTHESIS OF NUCLEOTIDES | CHEMOGENIX GMBH (DE) | 2003-05-01 | — | — | WO | disclosed |
| WO-2002012263-A1 | NUCLEIC ACID BINDING COMPOUNDS CONTAINING PYRAZOLO[3,4-D]PYRIMIDINE ANALOGUES OF PURIN-2,6-DIAMINE AND THEIR USES | ROCHE DIAGNOSTICS GMBH (DE) | 2002-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030198982-A1 | Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses | ADAR, NT5C3B, NT5C2 | ALDH1A1 1810/4885TSHR 4040/4885HPGD 2217/4885 |
| US-20060154256-A1 | Method for covalently attaching nucleosides and/or nucleotides on surfaces and method for determining coupling yields in the synthesis of nucleotides | NUDT1, PNP, NME2 | ALDH1A1 3207/4885TSHR 2116/4885HPGD 530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.