Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.75 |
| ▸ | TP53 | P04637 | 1/20 | 0.75 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.75 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.75 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.53 |
| ▸ | GABRP | O00591 | 2/20 | 0.50 |
| ▸ | GABRD | O14764 | 2/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.50 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.50 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.50 |
| ▸ | GABRE | P78334 | 2/20 | 0.50 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.50 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.50 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5874224 | 1.00 | TSHR (0.75) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL5076417 | 1.00 | TSHR (0.75) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL5318712 | 1.00 | TSHR (0.75) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL1062045 | 1.00 | TSHR (0.75) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL5874229 | 1.00 | TSHR (0.75) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL2223143 | 0.87 | TSHR (0.82) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL1924596 | 0.87 | TSHR (0.82) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL9261130 | 0.87 | TSHR (0.82) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL554796 | 0.87 | TSHR (0.82) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL11284804 | 0.87 | TSHR (0.82) | TSHRTP53EGLN1EGLN3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 237 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964827-B1 | VENTILATION INSERT | FREUDENBERG CARL KG (DE) | 2019-11-06 | — | — | EP | claimed |
| CN-105026638-A | Vane arrangement having alternating vanes with different trailing edge profile | ELLIOTT CO | 2015-11-04 | — | — | CN | claimed |
| CN-101013080-B | Sheath liquid for particle analyzer, method of preparing sheath liquid and particle analytic method using the sheath liquid | SYSMEX CORP | 2012-12-12 | — | — | CN | claimed |
| EP-1161565-B1 | USE OF SUPERABSORBENT POLYMERS FOR TREATING RAW SKINS, CORRESPONDING COMPOSITIONS AND METHODS AND RESULTING TREATED SKINS | SNF SA (FR) | 2009-10-28 | — | — | EP | claimed |
| CN-101013080-A | Sheath liquid for particle analyzer, method of preparing sheath liquid and particle analytic method using the sheath liquid | SYSMEX CORP (JP) | 2007-08-08 | — | — | CN | claimed |
| EP-1578826-B1 | SYNTHETIC MATERIAL DISPERSIONS | AMI AGROLINZ MELAMINE INT GMBH (AT) | 2007-06-20 | — | — | EP | claimed |
| US-20060173102-A1 | Synthetic material dispersions | AMI-AGROLINZ MELAMINE INTERNATIONAL GMBH (AT) | 2006-08-03 | — | — | US | claimed |
| EP-1294561-B1 | FIBRE COMPOSITES WITH EXCELLENT DIMENSIONAL STABILITY, WEATHER RESISTANCE AND FLAMEPROOFING PROPERTIES | AMI AGROLINZ MELAMINE INT GMBH (AT) | 2005-04-06 | — | — | EP | claimed |
| US-20260103885-A1 | Cementitious Panels with Swellable Materials and Methods of Providing a Moisture or Water Barrier in Cementitious Panels Using Swellable Materials | GOLD BOND BUILDING PRODUCTS LLC (US) | 2026-04-16 | — | — | US | disclosed |
| US-20250288972-A1 | Nanoporous Superabsorbent Particles with Low Non-Solvent Levels | KIMBERLY-CLARK WORLDWIDE, INC. | 2025-09-18 | — | — | US | disclosed |
| US-12337297-B2 | Nanoporous superabsorbent particles with low non-solvent levels | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2025-06-24 | — | — | US | disclosed |
| WO-2025129030-A1 | PROCESS FOR PRODUCING ABSORBENT SUBSTRATES | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2025-06-19 | — | — | WO | disclosed |
| US-20250052057-A1 | Cementitious Panels with Swellable Materials and Methods of Providing a Moisture or Water Barrier in Cementitious Panels Using Swellable Materials | BANK OF AMERICA, N.A., AS COLLATERAL AGENT | 2025-02-13 | — | — | US | disclosed |
| US-12194435-B2 | Nanoporous superabsorbent particles | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2025-01-14 | — | — | US | disclosed |
| EP-0690885-A1 | METHOD OF PRODUCTION OF COPOLYMERS OF POLYAMINO ACIDS | Calwood Chemical Industries, Inc. (US) | 1996-01-10 | — | — | EP | disclosed |
| EP-0690885-A4 | METHOD OF PRODUCTION OF COPOLYMERS OF POLYAMINO ACIDS | SRCHEM INC (US) | 1995-11-15 | — | — | EP | disclosed |
| WO-1994021710-A1 | METHOD OF PRODUCTION OF COPOLYMERS OF POLYAMINO ACIDS | SRCHEM, INC. (US) | 1994-09-29 | — | — | WO | disclosed |
| US-5292858-A | Method of production of copolymers of polyamino acids | SRCHEM INCORPORATED (US) | 1994-03-08 | — | — | US | disclosed |
| US-4076663-A | POLYMERIZING WITH UNSATURATED MONOMER, CROSSLINKING, HYDROLYZING | SANYO CHEMICAL INDUSTRIES, LTD. (JA) | 1978-02-28 | — | — | US | disclosed |
| US-4008126-A | Immobilization of proteins by in-situ polymerization | OWENS-ILLINOIS, INC. (US) | 1977-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260103885-A1 | Cementitious Panels with Swellable Materials and Methods of Providing a Moisture or Water Barrier in Cementitious Panels Using Swellable Materials | DSG1, AQP4, WAPL | TSHR 4831/4885TP53 115/4885EGLN1 724/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.